Investigation of the wound healing potential of Onosma hispidum root extract in rabbit models

Investigation of the wound healing potential of Onosma hispidum root extract in rabbit models

Authors

  • Asad Ali Department of Chemistry and Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad-38040, Pakistan.
  • Fatma Hussain Lecturer, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad-38040, Pakistan.
  • Muhammad Shahid Department of Chemistry and Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad-38040, Pakistan.

Keywords:

Onosma hispidum, excision wounds, petroleum jelly, wound contraction, histopathology

Abstract

Onosma hispidum Wall. (Boraginaceae) has historically been used to treat a wide assortment of diseases. Present study was conducted to investigate the wound healing activity of Onosma hispidum  root extracts in animal models. Excision wound were inflicted upon four groups of five rabbits each. Group 1 assigned as vehicle (negative control) was treated with petroleum jelly. Group 2 and 3 were treated with O. hispidum MeOH and n-hexane extracts. Group 4 (positive control) was accorded standard drug polyfax.  Healing was assessed by the percentage of wound contraction and histopathological analysis. Animal models treated with n-hexane and MeOH extracts ointments of O. hispidum had significantly (p < 0.05) positive healing effects as compared to the negative controls. Significant reduction (54-56%) in terms of percentage wound contractions were observed in plant treated groups as compared to the vehicle control. O. hispidum treatment resulted in partially developed dermal layer with stratified squmaous, stratum corneum and stratum germinatium development. Although major bioactive principles involved are yet to be determined, this investigation reveals the potential of O. hispidum for use as a natural wound curing agent.

Author Biographies

Asad Ali, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad-38040, Pakistan.

Student, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad-38040, Pakistan.

Fatma Hussain, Lecturer, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad-38040, Pakistan.

lecturer

Muhammad Shahid, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad-38040, Pakistan.

Associate professor

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Published

20-10-2015

Issue

Vol. 17 No. 3 (2015)

Section

Original articles

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Ali A, Hussain F, Shahid M. Investigation of the wound healing potential of Onosma hispidum root extract in rabbit models. Progr Nutr [Internet]. 2015 Oct. 20 [cited 2025 Mar. 4];17(3):245-9. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/3777