Comparison of Creatine Kinase Myocardial Band (CK-MB) and High Sensitive Troponin I (hsTnI) Values Between Athletes and Sedentary People

Main Article Content

Deniz Çakaroğlu
Mustafa Oğuzhan Kaya

Keywords

CK-MB, hsTnI, Sports, Women, Men

Abstract

Study Objectives: This study was conducted to examine and compare CK-MB and hsTnI values between people who exercise regularly and actively and those who do not, considering that men have a higher muscle mass than women, but also the higher amount of estrogen secreted in women. Methods: The test group was composed of 18 men, 17 women, a total of 35 (23.28±4.09 years) persons who engaged in active sports with no problems in terms of blood measurement. The control group was formed from a total of 34 (24.50±5.60 years) persons, including 17 men and 17 women with a sedentary lifestyle that do not engage any sport. Statistical analyses were evaluated in the SPSS program and the Independent Samples t Test was used to determine the difference between the groups. Results: The CK-MB values of active athletes were found to be less than 5 U/L (1.95±1.04), which is the mean value, and higher values than the control group. hsTnI values have a significant difference between the test group and the control group and this difference was found to below the middle level. The mean CK-MB and hsTnI values of men participants were found to be statistically significant, with more than the mean value of women participants. The men test group CK-MB values were found to be higher than the control group and there was a significant difference (p<0.05). There was no statistically significant difference in hsTnI values between men’s test and control groups. Conclusion: As a result of CK-MB and hsTnI measurements of the women test and control groups, it was observed that there was no significant difference between them. Herewith, it has been revealed that there are differences in CK-MB and hsTnI values among those who do active sports compared to those who do not, but also among women and men.

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References

1. Aakre KM, Omland T. Physical activity, exercise and cardiac troponins: Clinical implications. Prog Cardiovasc Dis 2019; 62(2):108-115.
2. Mert H, Yılmaz H, Irak K, et al. Investigation of the protective effect of kefir against isoproterenol induced myocardial infarction in rats. Korean J Food Sci Anim Resour 2018; 38(2):259-272.
3. Kagawa Y, Toyofuku M, Masaoka Y, et al. Comparison of heart-type fatty acid binding protein and sensitive troponin for the diagnosis of early acute myocardial infarction: Int J Cardiol 2013; 166(2): 347-351.
4. Keller T, Zeller T, Ojeda F, et al. Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction. JAMA 2010; 306(24): 2684-2693
5. Kilcullen N, Visvanathan K, Das R, et al. Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk patients across the range of troponin values. A.S. J. Am. Coll. Cardiol 2007; 50 (21): 2061-2067.
6. Ye XD, He Y, Wang S, et al. Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis. Acta Pharmacol Sin. 2018; 39 (7): 1155-1163.
7. Kleine AH, Glatz JFC, Vannieuwenhoven FA, et al. Release of Heart Fatty Acid-Binding Protein into Plasma After Acute Myocardial-Infarction in Man. Mol Cell Biochem 1992; 116 (1-2): 155-162.
8. Krause EG, Rabitzsch G, Noll F, et al. Glycogen phosphorylase isoenzyme BB in diagnosis of myocardial ischaemic injury and infarction. Mol Cell Biochem 1996; 161: 289-295.
9. Lejay A, Fang F, John R, et al. Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus. J Mol Cell Cardiol 2015; (91): 11-22.
10. Li HB, Yao WF, Liu ZP, et al. Hyperglycemia Abrogates Ischemic Post conditioning Cardio protection by Impairing. Signaling in Diabetic Rats. Diabetes 2016; 65(4): 942-955.
11. Li WJ, Chen XM, Nie XY, et al. Early diagnostic and prognostic utility of high-sensitive troponin assays in acute myocardial infarction: a meta-analysis. Intern med J 2015; 45 (7): 748-756.
12. Lillpopp L, Tzikas S, Ojeda F, et al. Prognostic Information of Glycogen Phosphorylase Isoenzyme BB in Patients with Suspected Acute Coronary Syndrome. AM J Cardiol 2012; 110 (9): 1225-1230.
13. Liu DN, Qi X, Li Q, et al. Increased complements and high-sensitivity C-reactive protein predict heart failure in acute myocardial infarction. Biomedıcal Reports 2016; 5(6): 761-765.
14. Lopes RD, Lokhnygina Y, Hasselblad V, et al. Methods of creatine kinase-MB analysis to predict mortality in patients with myocardial infarction treated with reperfusion therapy. Trials 2013; 2(14): 14-123.
15. Demir M, Filiz K. Effects of sport exercises on human organism. Gazi University the Kırşehir Education Faculty 2004; 5(2): 109-114.
16. Matthew A, Nystoriak AB. Cardiovascular Effects and Benefits of Exercise. FRONT MED-PRC. 2018; 5:135.
17. Öztürk Ç. Effects of Acute Pre-exercise Glicerol Loading on Some Biochemical Parameters Including Lactate and Aerobic Power. Selçuk University, The Institute of Health Science. Master Thesis, Konya, 2009.
18. Aydın Y, Akdeniz YS, Çakmak F, et al. Analysis of the Patients with Elevated Creatinine Kinase (CK) Level at Emergency Department. Jamer 2018; 3(3):1-24.
19. Sak S, Erdemoğlu M, Ağaçayak E, et al. Evaluation of serum Troponin I Levels in preeclampsia. Dicle Med J 2015; 42 (2): 186-191.
20. Wen X, Guo B, Gong Y. Cardiodynamicsgram: a novel tool for monitoring cardiac function in exercise training, J Sport SCI 2018; 36(22): 2583-2587
21. Hazar S. Exercise Induced Skeletal Muscle and Myocardial Damage. Spormetre 2004; 2(3): 119-126.
22. Karakükçü Ç, Polat Y, Polat YA, et al. Effects of Exogenous Coenzyme Q 10 And Zinc Supplementation on Performance and Muscular Injury in Young Amateur Boxers, Jamer 2019; 4(2);37-46.
23. Algül S. Özçelik O. Determination of the Effects of Acute Exercise On Creatine Kinase, Creatine Kinase-Myocardial Isoenzyme Levels in Sedentary Male Subjects. Fırat University Medical Journal of Health Sciences. 2016; 30 (2): 51 - 55.
24. Şahin FB. The Effect of Different Recovery Types on The Muscle Injury and Cytokin Release. Inonu University the Institute of Health Science. Master Thesis. Malatya 2018.
25. Kayhan RF. The Effect of Different Weight Training on Blood Parameters and Serum Creatine Kinase. Balıkesir University the Institute of Health Science. Master Thesis. Balıkesir, 2014.
26. Kaya A. The Evaluation of Cardiac Effects of Sportsmen Exercise by Biochemical Parameters. Atatürk University the Institute of Health Science. Master Thesis. Erzurum 2014.
27. Ramaekers D, Ector H, Aubert AE, et al. Heart rate variability and heart rate in healthy volunteers. Is the female autonomic nervous system cardio protective? EUR Heart J 1998; 19(9):1334-41.
28. Simone GDE, Devereux RB, Daniels SR, et al. Gender differences in left ventricular growth. Hypertension 1995; 26:979–83.
29. R Zak. Development and proliferative capacity of cardiac muscle cells. Circ Res 1974; 35(2):17–26.
30. Prabhavathi K, Tamarai KS, Poornima KN, et al. Role of Biological Sex in Normal Cardiac Function and in its Disease Outcome2014; 8(8): BE01–BE04.
31. Sullivan MJ, Cobb FR, Higginbotham MB. Stroke volume increases by similar mechanisms during upright exercise in normal men and women. AM J Cardiol 1991; 67:1405–12.
32. Higginbotham MB, Morris KG, Coleman RE, et al. Sex related differences in the normal cardiac response to upright exercise. Circulation. 1984; 70:357–66.
33. Brancaccio P, Maffulli N, Limongelli FM. Creatine kinase monitoring in sport medicine. Brit Med Bull 2007; 81-82:209-230.
34. Taheri S, Pilehvarian AA, Akbari N, et al. Association between troponin I level and cardiovascular risk factors in asymptomatic hemodialysis patients. J Res Pharm Pract 2016; 5(2):101‐105.
35. Wettersten N, Maisel A. Role of Cardiac Troponin Levels in Acute Heart Failure. CFR 2015; 1(2):102–6.
36. Kousa O, Amr Essa, Ahsan M, et al. The Impact of Routine Cardiology Consultation On Critically Ill Patients with Elevated Troponin Levels. J. Am. Coll. Cardiol 2020; 75 (11 Supplement 1) 196.
37. Allan JJ, Feld RD, Russell AA, et al. Cardiac Troponin I Levels Are Normal or Minimally Elevated After Transthoracic Cardioversion. J. Am. Coll. Cardiol 1997; 30(4): 1052-1056.
38. James L, Januzzi JR, Gerasimos F, et al. Troponin elevation in patients with heart failure: on behalf of the third Universal Definition of Myocardial Infarction Global Task Force: Heart Failure Section. EHJ 2012; 33(18): 2265–2271.
39. Carlton E, Greenslade J, Cullen L, et al. Evaluation of High-Sensitivity Cardiac Troponin I Levels in Patients with Suspected Acute Coronary Syndrome. JAMA Cardiology 2016; 1(4):405–412.
40. Rahnama N, Faramarzi M, Gaeini AA. Effects of Intermittent Exercise on Cardiac Troponin I and Creatine Kinase-MB. Int J Prev Med 2011; 2(1):20‐23.
41. Aengevaeren VL, Hopman MTE, Thompson PD, et al. Exercise-Induced Cardiac Troponin I Increase and Incident Mortality and Cardiovascular Events. Circulation 2019; 140(10):804-814.
42. Eijsvogels TM, Shave R, Van DJK, et al. Exercise-induced cardiac troponin release: real-life clinical confusion. Curr Med Chem 2011; 18(23):3457-61.
43. Parsons TJ, Sartini C, Welsh P, et al. Objectively measured physical activity and cardiac biomarkers: A cross sectional population based study in older men. International Journal of Cardiology 2018; 254:322‐327.