Nutritional status assessment in patients with chronic pancreatitis
Nutritional status in chronic pancreatitis
Keywords:chronic pancreatitis, malnutrition, nutritional study, anthropometric parameters, insulin-like growth factor I
Background and aim: Malnutrition is a major problem in patients with chronic pancreatitis (CP); nevertheless, there has been scant research on their nutritional assessment and management. The study objective was to perform a complete nutritional assessment in patients with CP and identify anthropometric and analytical parameters that facilitate the early detection of malnutrition. Methods: Data were gathered from 31 patients with CP on food frequency questionnaire results, anthropometric measurements, and analytical parameters.
Results: Around half of the patients were overweight or obese. Around half consumed sweets, snacks, soft drinks, and red meats daily and reported a low intake of fish, vegetables, and nuts; one-quarter of patients had low prealbumin and insulin-like growth factor 1 levels; almost half had elevated total cholesterol.
Conclusions: Measures need to be taken to improve the diet of patients with CP and to monitor their body composition. Data on levels of insulin-like growth factor type 1, a little used biochemical parameter, proved highly useful for the early detection of malnutrition in these patients.
Arvanitakis M, Ockenga J, Bezmarevic M, et al. ESPEN guideline on clinical nutrition in acute and chronic pancreatitis. World J Gastroenterol 2020; 39 (3): 612-631.
Beyer G, Habtezion A, Werner J, Lerch MM, Mayerle J. Chronic pancreatitis. Lancet 2020; 396 (10249): 499-512.
Hart PA, Conwell DL. Chronic Pancreatitis: Managing a Difficult Disease. Am J Gastroenterol 2020; 115 (1): 49-55.
O'Brien SJ, Omer E. Chronic Pancreatitis and Nutrition Therapy. Nutr Clin Pract 2019; 34 Suppl 1: S13-S26.
Phillips ME, Robertson MD, Hart KH, Kumar R, Pencavel TD. Long-term effects of clinical interventions on nutritional status in patients with chronic pancreatitis - A systematic review. Clin Nutr ESPEN 2022; 48: 178-185.
Tinju J, Reshmi S, Rajesh G, Balakrishnan V. Anthropometric, biochemical, clinical and dietary assessment for malnutrition in South Indian patients with chronic pancreatitis. Trop Gastroenterol 2010; 31 (4): 285-290.
Gupte A, Goede D, Tuite R, Forsmark CE. Chronic pancreatitis. BMJ 2018; 361: k2126.
Duggan SN, Smyth ND, O'Sullivan M, Feehan S, Ridgway PF, Conlon KC. The prevalence of malnutrition and fat-soluble vitamin deficiencies in chronic pancreatitis. Nutr Clin Pract 2014; 29: 348-354.
Spagnolo DM, Greer PJ, Ohlsen CS, et al. Acute and chronic pancreatitis disease prevalence, classification, and comorbidities: a cohort study of the UK BioBank. Clin Transl Gastroenterol 2022; 13 (1): e00455.
Kuan LL, Dennison AR, Garcea G. Prevalence and impact of sarcopenia in chronic pancreatitis: a review of the literature. World J Surg 2021; 45 (2): 590-597.
Aranceta-Bartrina J, Partearroyo T, López-Sobaler AM, et al. Updating the food-based dietary guidelines for the spanish population: the Spanish Society of Community Nutrition (SENC) Proposal. Nutrients 2019; 11 (11): 2675.
Armbrecht U. Chronic pancreatitis: weight loss and poor physical performance - experience from a specialized rehabilitation centre. Rehabilitation 2001; 40 (6): 332-336.
Khatua B, El-Kurdi B, Singh VP. Obesity and pancreatitis. Curr Opin Gastroenterol 2017; 33 (5): 374-382.
Wiese ML, Gärtner S, von Essen N, et al. Malnutrition is highly prevalent in patients with chronic pancreatitis and characterized by loss of skeletal muscle mass but absence of impaired physical function. Front Nutr 2022; 9: 889489.
Rasmussen HH, Irtun O, Olesen SS, Drewes AM, Holst M. Nutrition in chronic pancreatitis. World J Gastroenterol 2013; 19 (42): 7267-7275.
Goodarzi MO, Petrov MS, Andersen DK, Hart PA. Diabetes in chronic pancreatitis: risk factors and natural history. Curr Opin Gastroenterol 2021; 37 (5): 526-531.
de Souza RGM, Schincaglia RM, Pimentel GD, Mota JF. Nuts and human health outcomes: a systematic review. Nutrients 2017; 9 (12): 1311.
Singh VK, Haupt ME, Geller DE, Hall JA, Quintana Diez PM. Less common etiologies of exocrine pancreatic insufficiency. World J Gastroenterol 2017; 23 (39): 7059-7076.
Lindkvist B, Domínguez-Muñoz JE, Luaces-Regueira M, Castiñeiras-Alvariño M, Nieto-Garcia L, Iglesias-Garcia J. Serum nutritional markers for prediction of pancreatic exocrine insufficiency in chronic pancreatitis. Pancreatology 2012; 12: 305-310.
Smith SH. Using albumin and prealbumin to assess nutritional status. Nursing 2017; 47 (4): 65-66.
Dichtel LE, Bjerre M, Schorr M, et al. The effect of growth hormone on bioactive IGF in overweight/obese women. Growth Horm IGF Res 2018; 40: 20-27.
Nicholls AR, Holt RI. Growth Hormone and Insulin-Like Growth Factor-1. Front Horm Res 2016; 47: 101-114.
DePalma RG, Hayes VW, O'Leary TJ. Optimal serum ferritin level range: iron status measure and inflammatory biomarker. Metallomics 2021; 13 (6): mfab030.
Campos del Portillo R, Palma Milla S, García Váquez N, et al. Assessment of nutritional status in the healthcare setting in Spain. Nutr Hosp 2015; 31 Suppl 3: 196-208.
Diéguez-Castillo C, Jiménez-Luna C, Prados J, Martín-Ruiz JL, Caba O. State of the art in exocrine pancreatic insufficiency. Medicina (Kaunas) 2020; 56 (10): 523.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.