Heavy metal residues in milk and dairy products produced in Northern Cyprus

Main Article Content

Kamil Dağcılar
Ceren Gezer

Keywords

milk consumption, heavy metals, public health nutrition, food safety, potential health risk

Abstract

Background: The present study aimed to determine the heavy metal concentrations (75As, 111Cd, 208Pb, 65Cu, 200Hg) in milk and dairy products produced in Northern Cyprus with a view to evaluating the daily metal intake and potential health risks.


Method: The study was conducted in a total of 616 individuals between the ages of 18 and 65, and the average daily consumption of milk and dairy products, in addition to body weight, were determined. Heavy metal concentrations in raw milk (cow, sheep, goat) and the most commonly consumed packaged milk products (UHT milk, yogurt, halloumi, lor, kashar, and white cheese) were determined by inductively coupled plasma-mass spectrometry (ICP-MS). Samples were taken from each product in triplicate, resulting in the analysis of a total of 27 samples. For evaluation of the potential health risks, the Health Risk Index (HRI) and Total HRI (THRI) were calculated using the results of packaged dairy product consumption, daily intake of metal, and oral reference level (RfD) (HRI<1, THRI<1 safe limits). Moreover, heavy metal concentrations were compared with maximum permissible limits (MPL).


Results: As residue was detected only in raw sheep’s milk samples (0.33±0.58 μg/kg). The average As, Cd, Pb, Cu, and Hg residues in packaged products were 4.55±6.19 (range: 0.00-25.00 μg/kg), 14.44±20.65 (range: 0.00-58.00 μg/kg), 6.83±19.03 (range: 0.00-81.00 μg/kg), 237.38±215.22 (range: 0.00-738.00 μg/kg), and 4.61±6.37 (range: 0.00-24.00 μg/kg), respectively. In addition, the calculated HRI and THRI values were below 1.


Conclusions: According to the HRI and THRI results, no possible health risks were determined with respect to consumption of the analyzed products. Cd residue was higher than the MPL in yogurt, halloumi, and UHT milk samples, while Pb residue was higher than the MPL in halloumi samples, and Cu residue was higher than the MPL in yogurt, halloumi, white cheese, kashar, and lor samples. It is important to control all steps that may cause heavy metal contamination during the processing of milk.

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References

1. Djamgoz MB, Akun E, Arslan B, Onbasi R, Nazif S, Besler H. Cancer in North Cyprus: 1. Current status, an overview. Cyprus J Med Sci 2017; 1: 13-8.
2. Akun ME, Yamacı RF, Charalambous C, Lechtvich S, Djamgoz MB. The distribution of carcinogenic heavy metals in Cyprus soil. In Survival and Sustainability. Springer Berlin Heidelberg 2010 (pp:353-359).
3. Abbas BF, Al-Jubori WMK, Abdullah AM, Sha'aban HK, Mohammed MT. Environmental Pollution with the Heavy Metal Compound. Res J Pharm Technol 2018; 11 (9):4035-4041.
4. Coşkun T, Şanlı T. Süt ve süt ürünlerinde kalıntılar. Academic Food Journal 2016; 14: 67-74.
5. Ali H, Khan E, Sajad MA. Phytoremediation of heavy metals—concepts and applications. Chemosphere 2013; 91 (7):869-881.
6. Danish M, Chan KW. MILK: Carrier of Heavy Metals from Crops through Ruminant Body to Human Beings. J Chem Soc Pak 2016; 38 (1): 39.
7. Younus M, Abbas T, Zafar M, et al. Assessment of heavy metal contamination in raw milk for human consumption. S Afr J Anim Sci 2016; 46 (2):166-169.
8. Meshref AM, Moselhy WA, Hassan NEHY. Heavy metals and trace elements levels in milk and milk products. J Food Meas Charact 2014; 8 (4):381-388.
9. Martí-Cid R, Llobet JM, Castell V, Domingo JL. Dietary intake of arsenic, cadmium, mercury, and lead by the population of Catalonia, Spain. Biol Trace Elem Res 2008; 125 (2):120-132.
10. Enb A, Abou-Donia MA, Abd-Rabou NS, Abou-Arab AAK, El-Senaity MH. Chemical composition of raw milk and heavy metals behavior during processing of milk products. Glob Vet 2009; 3 (3):268-275.
11. İstanbulluoğlu H, Oğur R, Tekbaş ÖF, Bakır B. Süt ve süt ürünlerinde ağır metal kirliliği. Turk J Med Sci 2013; 33 (2):410-419.
12. Tarakci Z, Dağ B. Mineral and heavy metal by inductively coupled plasma optical emission spectrometer in traditional Turkish yogurts. Int J Phys Sci 2013; 8 (19):963-966.
13. Maas S, Lucot E, Gimbert F, Crini N, Badot PM. Trace metals in raw cows’ milk and assessment of transfer to Comté cheese. Food Chem 2011; 129 (1):7-12.
14. Bilandzic N, Dokic M, Sedak et al. Trace element levels in raw milk from northern and southern regions of Croatia. Food Chem 2011; 127: 63-66.
15. Tajkarimi M, Faghih MA, Poursoltani H, Nejad AS, Motallebi AA, Mahdavi H. Lead residue levels in raw milk from different regions of Iran. Food Control 2008; 19:495-498.
16. Ayar A. Sert D. Akm N. The trace metal levels in milk and dairy products consumed in middle Anatolia-Turkey. Environ Monit Assess 2009; 152: 1-12.
17. Deeb AMM. Trace metals concentrations in cheese collected from Kafr El-Sheikh governorate, Egypt. Assiut Vet Med J 2010; 56 (127):75-84.
18. Malhat F, Hagag M, Saber A, Fayz AE. Contamination of cows milk by heavy metal in Egypt. Bull Environ Contam Toxicol 2012; 88 (4):611-613.
19. Temiz H, Soylu A. Heavy metal concentrations in raw milk collected from different regions of Samsun, Turkey. Int J Dairy Technol 2012; 65 (4):516-522.
20. Rahimi E. Lead and cadmium concentrations in goat, cow, sheep and buffalo milks from different regions of Iran. Food Chem 2013; 136: 389-391.
21. Pekcan, G. Beslenme Durumunun Saptanması. Baysal A, Aksoy M, Besler HT, Bozkurt N, Keçecioğlu S, Mercanlıgil SM et al. Diyet El Kitabı 2011; (p. 77). Ankara: Hatiboğlu.
22. Agilent Technologies. Last access 7 November 2019 web:https://www.agilent.com/
23. Codex Alimentarius Comission. Joint FAO/WHO. General standard for contaminants and toxins in food and feed. Codex Stand 2019; 193-1995.
24. Arianejad M, Alizadeh M, Bahrami A, Arefhoseini SR. Levels of Some Heavy Metals in Raw Cow's Milk from Selected Milk Production Sites in Iran: Is There any Health Concern? Health Promot Perspect 2015; 5 (3):176.
25. Sobhanardakani S. Human Health Risk Assessment of Cd, Cu, Pb and Zn through Consumption of Raw and pasteurized Cow’s Milk. Iran J Public Health 2018; 47 (8):1172.
26. Stahn A, Terblance E, Gunga HC. Use of Bioelectrical Impedance: General Principles. V. R. Preddy, Handbook of Anthropometry, London: Springer 2012; (p:80).
27. Guo J, Yue T, Li X, Yuan Y. Heavy metal levels in kiwifruit orchard soils and trees and its potential health risk assessment in Shaanxi, China. Environ Sci Pollut Res Int 2016; 23 (14):14560-14566.
28. Mahmood A, Malik RN. Human health risk assessment of heavy metals via consumption of contaminated vegetables collected from different irrigation sources in Lahore, Pakistan. Arab J Chem 2014; 7 (1):91-99.
29. Joint FAO/WHO Expert Committee on Food Additives (JECFA). Safety evaluation of certain food additives and contaminants. Includes all updates up to the 78th JECFA (November 2013). WHO Food Additives Series. Last access 7 November 2019. web:http://apps.who.int/food-additives-contaminants-jecfadatabase/search.aspx.
30. Non-Carcinogen Tolerable Daily Intake (TDI) Values from US-EPA, Adapted from US-EPA region II (2007) ;(US-EPA IRIS, 2006). Last Access: 7 November 2019 web:http://cfpub.epa.gov/ncea/iris/index.cfm?fuseaction=iris.showSubstance
31. Qin LQ, Wang XP, Li W, Tong X, Tong WJ. The minerals and heavy metals in cow's milk from China and Japan. J. Health Sci 2009; 55 (2):300-305.
32. Licata P, Di Bella G, Potortì AG, Lo Turco V, Salvo A, Dugo GM. Determination of trace elements in goat and ovine milk from Calabria (Italy) by ICP-AES. Food Addit Contam Part B Surveill 2012; 5 (4):268-271.
33. Tona GO, Adetunji VO, Ameen SA, Ibikunle AO. Evaluation of lead and cadmium heavy metal residues in milk and milk products sold in Ogbomoso, Southwestern Nigeria. Pak J Nutr 2013; 12 (2):168.
34. Ziarati P, Shirkhan F, Mostafidi M, Zahedi MT. An overview of the heavy metal contamination in milk and dairy products. Acta Sci Pharm Sci 2018; 2 (7):8-21.
35. Dündar Y, Aslan R. Effects of lead as a life surrounding heavy metal. J Food Meas Charact 2005; 6 (2):1-5.
36. Özbolat G, Tuli A. Ağır metal toksisitesinin insan sağlığına etkileri. Arch Med Res 2016; 25 (4):502-521.
37. Abou-Arab AAK, Abou-Donia MA, Enb A. Chemical composition, metals content and pesticide residues in raw, pasteurized and UHT milk and their dietary intake. J Egypt Soc Toxicol 2008; 39: 111-121.
38. Akhtar S, Ismail T, Riaz M, Shahbaz M, Amin K. Minerals and heavy metals in raw and ultra heat-treated commercial milk in Pakistan. Int. J. Food Allied Sci 2015; 1 (1):18-24.
39. Khan N, Jeong IS, Hwang IM, et al. Analysis of minor and trace elements in milk and yogurts by inductively coupled plasma-mass spectrometry (ICP-MS). Food Chem 2014; 147: 220-224.
40. Shahbazi Y, Ahmadi F, Fakhari F. Voltammetric determination of Pb, Cd, Zn, Cu and Se in milk and dairy products collected from Iran: An emphasis on permissible limits and risk assessment of exposure to heavy metals. Food Chem 2016; 192:1060-1067.
41. Yüzbaşı N, Sezgin E, Yildirim Z, Yildirim M. Changes in Pb, Cd, Fe, Cu and Zn levels during the production of kaşar cheese. J Food Qual 2009; 32 (1):73-83.
42. Mendil D. Mineral and trace metal levels in some cheese collected from Turkey. Food Chem 2006; 96 (4):532-537.
43. Ayar A, Sert D, Akın N. Konya’da tüketime sunulan süt ve ürünlerinin ağır metal içeriklerinin belirlenmesi. Selcuk j. agric. food sci 2007; 21 (41):58-64.
44. Christophoridis C, Kosma A, Evgenakis E, Bourliva A, Fytianos K. Determination of heavy metals and health risk assessment of cheese products consumed in Greece. J Food Compost Anal 2019; 103238.
45. Örün E, Yalçın SS. Kursun, civa, kadmiyum: çocuk sağlığına etkileri ve temasın belirlenmesinde saç örneklerinin kullanımı. Ankara Univ J Environ Sci 2011; 3 (2):73-81.
46. Öksüztepe G, Karatepe P, Özçelik M, İncili GK. Tulum Peyniri ve Taze Beyaz Peynirlerin Mineral Madde ve Ağır Metal İçerikleri. Fırat Univ Vet j health sci 2013; 27 (2):93-97.
47. Demirözü EB, Saldamli I. Variation in some heavy metals during the production of white cheese. Int J Dairy Technol 2000; 53 (3):96-99.
48. Rezaei M, Dastjerdi HA, Jafari H, et al. Assessment of dairy products consumed on the Arakmarket as determined by heavy metal residues. Health 2014; 6 (5):323.
49. Özlü H, Aydemir AM, Urçar S, Atasever M. Erzurum'da Tüketime Sunulan Kaşar Peynirlerinin Mineral Madde İçeriği ve Ağır Metal Kontaminasyonu. Kafkas Univ Vet Fak Derg 2012; 18 (2):205-208.
50. Reilly C. Metal contamination of food: its significance for food quality and human health. John Wiley & Sons. 3rd Edition 2008; 160-165.