Main Article Content
antimicrobial, honey, propolis
Humans have consumed bee products for thousands of years due to their numerous health benefits. Honey is an invaluable substance made of a combination of nectar and pollen collected by bees from flowers. Honey contains carbohydrates, organic acids, proteins, amino acids, vitamins and minerals. It has been used as an effective medicinal product since ancient times for the treatment of skin burns, wound ulcers tumours and gastrointestinal disorders as well as an antibacterial and antifungal agent (1,9).
Propolis, also referred to as bee glue, is a resinous hive product made of substances that honey bees collect from various plant sources and then mix with their own saliva and beeswax. Propolis contains various chemical compounds such as polyphenols, terpenoids, steroids, coumarin, amino acids and inorganic compounds (10-11).
Despite the fact that propolis has been known since ancient times, it has become the focus of great interest in recent years as a useful substance in medicines and cosmetics. Propolis exhibits antibacterial, antifungal, antiviral, antioxidant, antitumor and anti-inflammatory activities (12,18).
The composition of honey and propolis vary based on their plant origin (11-19); therefore, the aim of this study was to examine the natural microflora, antimicrobial effect and total protein and fatty acid contents of five types of honey and five types of propolis sold in Turkish markets.
1. Conti ME. Lazio region (central Italy) honeys: a survey of mineral content and typical quality parameters. Food Control, 2000, 11:459–463.
2. Molan PC. Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol, 2001, 2:13–19.
3. Cooper RA, Halas E, Molan PC. The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns. J Burn Care Rehabil, 2002, 23:366–370.
4. Dunford C, Cooper R, Molan PC, White R. The use of honey in wound management. Nurs Stand, 2000, 15:63–68.
5. Lusby PE, Coombes A, Wilkinson JM. Honey: a potent agent for wound healing? J Wound Ostomy Continence Nurs, 2002, 29:295–300.
6. Jones S. The use of honey in wound management. Nursing Standard, 2006, 20:52.
7. Hamzaoglu I, Saribeyoglu K, Durak H, Karahasanoglu T, Bayrak İ, Altug T, Sirin F, Sarıyar M. Protective covering of surgical wounds with honey impedes tumor implantation. Arch Surg, 2000, 135:1414–1417.
8. Patricia EL, Alexandra LC, Jenny MW. Bactericidal activity of different honeys against Pathogenic bacteria. Arch Med Res, 2005, 36:464–467.
9. Wilkinson JM, Cavanagh MA. Antibacterial activity of 13 honeys against Escherichia coli and Pseudomonas aeruginosa. J Med Food, 2005, 8:9100–103.
10. Kartal M, Yıldız S, Kaya S, Kurucu S, Topçu G. Antimicrobial activity of propolis samples from two different regions of Anatolia. J Ethnopharmacol, 2003, 86:69–73.
11. Choi YM, Noh DO, Cho SY, Suh HJ, Kim KM, Kim JM. Antoxidant and antimicrobial activities of propolis from several regions of Korea. Trends Food Sci Techno, 2006, 39: 756–761.
12. Silici S, Kutluca S. Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region. J Ethnopharmacol, 2005, 99:69–73.
13. Ugur A, Arslan T. An in vitro study on antimicrobial activity of propolis from Muğla province of Turkey. J Med Food, 2004, 7:90–94.
14. Kujumgiev A, Tsvetkova I, Serkedjieva Y, Bankova V, Christov R, Popov S. Antibacteria, antifungal and antiviral activity of propolis of different geographic origin. J Ethnopharmacol, 1999, 64:235–240.
15. Isla MI, Moreno MN, Sampietro AR, Vattuone MA. Antioxidant activity of Argentina propolis extracts. J Ethnopharmacol, 2001, 76:165–170.
16. Kumazawa S, Hamasaka T, Nakayama T. Antioxidant activity of propolis of different geographic origins. Food Chem, 2004, 84:329–339.
17. Pisco L, Kordian M, Peseke K, Feist H, Michalik D, Estrada E, Carvalho J, Hamilton G, Rando D, Quincoces J. Synthesis of compounds with antiproliferative activity as analogues of prenylated natural products existing in Brazilian propolis. Eur J Med Chem, 2006, 41:401–407.
18. Banskota AH, Tezuka Y, Kadota S. Recent progress in pharmacological research of propolis. Phytother Res, 2001, 15:561–571.
19. Uzel A, Sorkun K, Önçag Ö, Çoğulu D, Gençay Ö, Salih B. Chemical compositions and antimicrobial activities of four different Anatolian Propolis samples. Microbiol Res, 2005, 160:189–195.
20. Hara AR, Adin NS. Lipid extraction of tissues with a low-toxicity solvent. Anal. Biochem, 1978, 90:420–426.
21. Bradford MM. Rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle dye binding. Anal Biochem, 1976, 72:248–254.
22. Gür N, Dığrak M, Çobanoğlu D, Dilsiz N. Melitopalynological and antimicrobial properties of honey from Elaziğ (E Turkey). Acta Botanica Hungarica, 2001, 43:311–317.
23. Temiz A, Şener A, Tüylü ÖA, Sokun K, Salih B. Antibacterial activity of bee propolis samples from diff erent geographical regions of Turkey against two foodborne pathogens, Salmonella enteritidis and Listeria monocytogenes. Turk J Biol, 2011, 35:503–511.
24. Metzner J, Bekemeir H. Paintz M, Schneidewind E. Zurnantimicrobiellen wirksamkeit von propolis and propolisinhaltsstoffen. Pharmazie, 1979, 34:97–102.
25. Boulanouar B, Mounir H, Ahmed B and Abdelaziz G. Total phenolic, flavonoid contents and antioxidant activities of honey and propolis collected from the region of laghouat (south of algeria). International Journal of Pharmacognosy and Chinese Medicine, 2017, 1:2.