Effects of (+)- catechin + quercetin usage before exhaustion exercise on free radical and antioxidant enzyme levels (+)- catechin + quercetin usage before Exhaustion Exercise
Main Article Content
Keywords
Antioxidants, Catechin, Exhaustion Exercise, Free Radicals, Quercetin
Abstract
Study Objectives: The aim of this study was to determine the effects of the use of (+) -Catechin + Quercetin for 10 days before an exhaustion exercise on free radical and antioxidant enzyme levels. Methods: The study was performed on 12 male Wistar rats (260-320 gr.) from the same family and animals divided into two groups as a control and experimental group. After the first exhaustion exercise, rats in the experimental group used (+)- Catechin + Quercetin in addition to the standard laboratory diet and they performed the second exhaustion exercise. In the experimental group, 20 mg / kg (+) - Catechin + Quercetin substances were dissolved in dimethyl sulfoxide and given 1 ml / kg while the control group received 1 ml / kg 0.05% dimethyl sulfoxide by gavage in addition to standard laboratory diet daily for 10 days. SOD, CAT, GPx, GST, and MDA levels were measured by spectrophotometer. The IBM SPSS Statistics 24.0 was preferred for the statistical analysis. The repeated measures two-factor variance analysis was used to determine the difference between control and experimental groups. Results: It was determined that antioxidant enzyme levels (SOD, CAT, GPx, and GST levels) in rats using (+) - Catechin + Quercetin for 10 days before an exhaustion exercise were higher than those of the control group. Despite that, it was determined that MDA levels in rats using (+) - Catechin + Quercetin for 10 days before an exhaustion exercise were lower than those of the control group. Conclusion: It can be said that the use of (+)- Catechin + Quercetin can reduce the amount of MDA which is the end product of lipid peroxidation in exercise and may create a protective effect against free radicals and increase the levels of antioxidant enzymes and strengthen the antioxidant defense systems of the cells and have a positive effect on exercise performance.
References
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19- Kocabaş, N. (2008). Homosisteinin indüklediği oksidatif stres üzerinde quercetinin koruyucu etkisi. Master's thesis, Afyon Kocatepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Afyon, Türkiye.
20- Duarte, J., Pérez‐Palencia, R., Vargas, F., Angeles Ocete, M., Pérez‐Vizcaino, F., Zarzuelo, A., & Tamargo, J. (2001). Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. British journal of pharmacology, 133(1), 117-124.
21- Adewole, S. O., Caxton-Martins, E. A., & Ojewole, J. A. (2007). Protective effect of quercetin on the morphology of pancreatic β-cells of streptozotocin-treated diabetic rats. African Journal of Traditional, Complementary and Alternative Medicines, 4(1), 64-74.
22- Agarwal, R., Katiyar, S. K., Khan, S. G., & Mukhtar, H. (1993). Protection against ultraviolet B radiation‐induced effects in the skin of SKH‐1 hairless mice by a polyphenolic fraction isolated from green tea. Photochemistry and photobiology, 58(5), 695-700.
23- Akyüz, Ö. (2016). Effects of Different-Term Acute Swimming Exercises on Oxidative Stress Parameters in Rat Cerebellum Tissue. US-China Education Review B, 6(10), 600-608.
24- Demirci, N. (2017). Protective Effect of Prolonged Quercetin Supplement on Oxidative Stress and Antioxidant Enzyme Activities in Boxers. Studies on Ethno-Medicine, 11(2), 168-173.
25- Sadowska-Krępa, E., Domaszewski, P., Pokora, I., Żebrowska, A., Gdańska, A., & Podgórski, T. (2019). Effects of medium-term green tea extract supplementation combined with CrossFit workout on blood antioxidant status and serum brain-derived neurotrophic factor in young men: a pilot study. Journal of the International Society of Sports Nutrition, 16(1), 1-9.
26- Park, H. J., DiNatale, D. A., Chung, M. Y., Park, Y. K., Lee, J. Y., Koo, S. I., ... & Bruno, R. S. (2011). Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. The Journal of nutritional biochemistry, 22(4), 393-400.
27- Phachonpai, W., Wattanathorn, J., Muchimapura, S., Tong-Un, T., & Preechagoon, D. (2010). Neuroprotective effect of quercetin encapsulated liposomes: a novel therapeutic strategy against Alzheimer's disease. American Journal of Applied Sciences, 7(4), 480-485.
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29- Göktepe, M., & Günay, M. (2014). Quercetin uygulamasının egzersiz, serbest radikal ve antioksidan enzim düzeyleri üzerine etkisi. International Journal of Sport Culture and Science, 2(Special Issue 1), 775-788.
30- Durukan, E. (2019). Egzersizdeki Serbest Radikal ve Antioksidan Enzim Düzeylerine Catechin Uygulamasının Etkisi, Gazi Kitabevi, Ankara.
31- Dresser, G. K., Bailey, D. G., Leake, B. F., Schwarz, U. I., Dawson, P. A., Freeman, D. J., & Kim, R. B. (2002). Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine. Clinical pharmacology & therapeutics, 71(1), 11-20.
32- Malien-Aubert, C., Dangles, O., & Amiot, M. J. (2001). Color stability of commercial anthocyanin-based extracts in relation to the phenolic composition. Protective effects by intra-and intermolecular copigmentation. Journal of agricultural and food chemistry, 49(1), 170-176.
33- Ohtani, M., Kawabata, S., Kariya, S., Uchino, K., Itou, K., Kotaki, H., ... & Nishida, N. (2002). Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine. Yakugaku zasshi: Journal of the Pharmaceutical Society of Japan, 122(5), 323-329.
34- Silberberg, M., Morand, C., Manach, C., Scalbert, A., & Remesy, C. (2005). Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism. Life sciences, 77(25), 3156-3167.
35- Violi, F., Pignatelli, P., & Pulcinelli, F. M. (2002). Synergism among Flavonoids in Inhibiting Platelet Aggregation and H. Circulation, 105, e53.
36- Drabkin, D. L. (1946). Spectrophotometric studies XIV. The crystallographic and optical properties of the hemoglobin of man in comparison with those of other species. Journal of biological chemistry, 164(2), 703-723.
37- Marklund, S., & Marklund, G. (1974). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European journal of biochemistry, 47(3), 469-474.
38- Aebi, H. (1984). Catalase in vitro. In Methods in enzymology, 105, 121-126
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Durukan E. Effects of (+)- catechin + quercetin usage before exhaustion exercise on free radical and antioxidant enzyme levels: (+)- catechin + quercetin usage before Exhaustion Exercise . Progr Nutr [Internet]. 2020 Mar. 10 [cited 2024 Jul. 18];22(1):265-74. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/9041
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How to Cite
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Durukan E. Effects of (+)- catechin + quercetin usage before exhaustion exercise on free radical and antioxidant enzyme levels: (+)- catechin + quercetin usage before Exhaustion Exercise . Progr Nutr [Internet]. 2020 Mar. 10 [cited 2024 Jul. 18];22(1):265-74. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/9041
