The effect of short-term royal jelly supplement on testosterone levels in sedentary and healthy individuals Royal jelly and testosterone
Main Article Content
Keywords
testosterone, royal jelly, supplement
Abstract
This study with a placebo-controlled experimental design intends to investigate the effect of Royal Jelly (RJ) on the testosterone levels in sedentary men at a dose of 1000 mg/day. For this purpose, a total of 20 adult sedentary men aged 21 to 23 were included in this study. The subjects visited the laboratory every day for 15 days between 08:00 and 10:00 to get their portion of royal jelly. The subjects were randomly divided into two groups, namely the experimental group (n = 10 individuals, 1000 mg/day of Royal Jelly) and the placebo group (n = 10 individuals, corn starch mixed with 1000 mg/day of water) and they took royal jelly in glass vials at the same time. Blood samples were taken from both groups of subjects one day before and one day after the study and analyzed to determine their testosterone levels. 2x2 mixed factor ANOVA and LSD tests were used to analyze data obtained from the experimental and the placebo group. A sharp increase in the testosterone levels of the experimental group that took RJ for a short time was found to be statistically significant (p<0.05). The pre- and post-test values of the placebo group were not found to be statistically significant (p>0.05). The study shows that a 1000 mg/day dose of RJ supplements was effective in increasing testosterone levels in sedentary, healthy men.
References
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Delkhoshe-Kasmaıe, F; Malekınejad, H; Khoramjouy, M; Rezaeı-Golmısheh, A; Janbazeacyabar,H (2014) Royal jelly protects from taxol-induced testicular damages via improvement ofantioxidant status and up-regulation of E2f1. Systems Biology in Reproductive Medicine 60 (2): 80-88.
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Eshtiyaghi, M., Deldar, H., Pirsaraei, Z. A., and Shohreh, B. (2016). Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization. Theriogenology, 86(9). 2210-2221.
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Gasic, S., Vucevic, D., Vasilijic, S., Antunovic, M., Chinou, I., and Colic, M. (2007). Evaluation of the immunomodulatory activities of royal jelly components in vitro. Immunopharmacology and Immunotoxicology, 29(3-4), 521-536.
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Guo, H., Ekusa, A., Iwai, K., Yonekura, M., Takahata, Y., and Morimatsu, F. (2008). Royal jelly peptides inhibit lipid peroxidation in vitro and in vivo. Journal of nutritional science and vitaminology, 54(3), 191-195.
Guo, H., Kouzuma, Y., and Yonekura, M. (2009). Structures and properties of antioxidative peptides derived from royal jelly protein. Food Chemistry, 113(1), 238-245.
Hashimoto, M., Kanda, M., Ikeno, K., Hayashi, Y., Nakamura, T., Ogawa, Y., and Furukawa, S. (2005). Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of . the adult mouse brain. Bioscience, Biotechnology, and Biochemistry, 69(4), 800805.
Hassan, A (2009) Effect of royal jelly on sexual efficiency in adult male rats. Iraq J.Vet.Sci. 23: 155-160.
Hattori, N., Ohta, S., Sakamoto, T., Mishima, S., and Furukawa, S. (2011). Royal jelly facilitates restoration of the cognitive ability in trimethyltin-intoxicated mice. Evidence-based complementary and alternative medicine.
Herbert, E. W., Graham, J. M. (1992). The hive and the honey bee. 197-233.
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Huseın, M Q; Haddad, S G (2006) A new approach to enhance reproductive performance in sheep using royal jelly in comparison with equine chorionic gonadotropin. Animal Reproduction Science 93 (1-2): 24-33.
Huseın, M Q; Krıdlı, R T (2002) Reproductive responses following royal jelly treatment administered orally or intramuscularly into progesterone-treated Awassi ewes. Animal Reproduction Science 74 (1-2): 45-53.
Inoue, S. I., Koya-Miyata, S., Ushio, S., Iwaki, K., Ikeda, M., and Kurimoto, M. (2003). Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Experimental gerontology, 38(9), 965-969.
Jamnik, P., Goranovič, D., and Raspor, P. (2007). Antioxidative action of royal jelly in the yeast cell. Experimental gerontology, 42(7), 594-600.
Kamakura, M (2002) Signal transduction mechanism leading to enhanced proliferation of primary cultured adult rat hepatocytes treated with royal jelly 57kDa protein. Journal of Biochemistry 132 (6): 911-919.
Kamakura, M; Mıtanı, N; Fukuda, T; Fukushıma, M (2001) Antifatigue effect of fresh royal jelly in mice. Journal Of Nutrıtıonal Scıence And Vıtamınology 47 (6): 394-401.
Kamakura, M; Suenobu, N; Fukushıma, M (2001) Fifty-seven-kDa protein in royal jelly enhances proliferation of primary cultured rat hepatocytes and increases albumin production in the absence of serum.
Kohguchı, M; Inoue, S; Ushıo, S; Iwakı, K; Ikeda, M; Kurımoto, M (2004) Effect of royal jelly diet on the testicular function of hamsters. Food Science and Technology Research 10 (4): 420-423.
Kohno, K; Okamoto, I; Sano, O; Araı, N; Iwakı, K; Ikeda, M; Kurımoto, M (2004) Royal Jelly inhibits the production of proinflammatory cytokines by activated macrophages. Bioscience Biotechnology and Biochemistry 68 (1): 138-145.
Koya-Miyata, S., Okamoto, I., Ushio, S., Iwaki, K., Ikeda, M., and Kurimoto, M. (2004). Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism. Bioscience, Biotechnology, and Biochemistry, 68(4), 767-773.
Krıdlı, R T; Al Khetıb, S S (2006) Reproductive responses in ewes treated with eCG or increasing doses of royal jelly. Animal Reproduction Science 92 (1-2): 75-85.
Krıdlı, R T; Huseın, M Q; Humphrey, W D (2003) Effect of royal jelly and GnRH on the estrus synchronization and pregnancy rate in ewes using intravaginal sponges. Small Ruminant Research 49 (1):25-30.
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Taşdoğan AM, Pancar Z, Özdal M, Vural M, Pancar S, Birinci YZ. The effect of short-term royal jelly supplement on testosterone levels in sedentary and healthy individuals: Royal jelly and testosterone. Progr Nutr [Internet]. 2020 Mar. 10 [cited 2024 Jul. 18];22(1):275-80. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/8746
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Taşdoğan AM, Pancar Z, Özdal M, Vural M, Pancar S, Birinci YZ. The effect of short-term royal jelly supplement on testosterone levels in sedentary and healthy individuals: Royal jelly and testosterone. Progr Nutr [Internet]. 2020 Mar. 10 [cited 2024 Jul. 18];22(1):275-80. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/8746
