Uric acid independently correlates with sex-hormone binding globuline in postmenopausal women Relationship between uric acid and SHBG

Abstract

Background/Aim: Low sex-hormone binding globuline (SHBG) and high uric acid level are shown to be the independent predictors of many cardiometabolic diseases. However, it is unknown whether this two biomarkers are interrelated, and if so, whether this relationship is independent or it is mediated by some whether these factors. Therefore, the aim of the current study was to examine the potential relationship between serum SHBG and uric acid levels in the cohort of postmenopausal women. Methods: A total of 150 postmenopausal women encompassed this cross-sectional study. Biochemical and anthropometric data were obtained. Results: In univariate ordinal regression analysis, uric acid (Odds ratio (OR)=0.983, 95% Confidence Interval (CI) 0.978-0.989, p<0.001), high-density lipoprotein cholesterol (OR=4.135, 95% CI 2.004-9.291, p<0.001), high sensitivity C-reactive protein (OR=0.656, 95% CI 0.530-0.811, p<0.001), retinol-binding protein 4 (OR=0.962, 95% CI 0.931-0.995, p=0.023), and cystatin C (OR=0.004, 95% CI 0.000-0.079, p<0.001), were shown to be associated with SHBG level. However, multivariate ordinal regression analysis showed that only uric acid was independently associated with SHBG level in postmenopausal women (OR=0.990, 95% CI 0.983-0.988, p=0.018). Rise in uric acid concentration by 1 µmol/L decreased the probability of higher SHBG concentration by 1%. Nagelkerke R² for the Model was 0.464 which indicated that 46.4% of variation in SHBG concentration could be explained with this Model. Conclusion: Uric acid is independently associated with SHBG in postmenopausal women.