The relationship between nutritional status, serum folic acid and homocyteine levels in hemodialysis and peritoneal dialysis patients Nutritional status, serum folic acid and homocyteine levels

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Handan Akalin
Neslişah Rakicioğlu


nutritional status, dialysis, malnutrition, folic acid, vitamin B12, homocysteine




Background. Nutritional deficiencies and imbalances may be encountered in hemodialysis (HD) and peritoneal dialysis (PD) patients. The aim of this study was to investigate the relationship between nutritional status, and serum folic acid and homocytene levels in hemodialysis and peritoneal dialysis patients. Methods. Information about demographics and eating habits were recorded using questionnaire in 30 hemodialysis and 30 peritoneal dialysis patients. Subjective global assessment test was used to assess the nutritional status of the patients. Individual food consumption records were taken in three consecutive days. Also, serum vitamin B12, folate, homocysteine ​​levels and some blood parameters monitored were examined in the routine. Results. All of dialysis patients were found malnourished. Hemodialysis patients had lower body weight, body mass index, waist and hip circumferences than PD patients (p<0.05). Serum homocysteine levels of PD patients were higher than HD patients (p<0.05). Positive correlation was identified between serum homocysteine ​​and BUN levels, whereas there was an inverse relationship between homocysteine and vitamin B12 level, total protein, albumin level and malnutrition score (p<0.05).  In general, no significant difference was found between the nutrient consumption of HD and PD patients. Conclusion. Nutritional status of patients with PD were found worse than HD patients. Assessment of nutritional status at periodicaly is important for prevention of malnutrition and early intervention in dialysis patients. Dietary folic acid, vitamin B12, vitamin B6 and protein intake may be improved by foods or supplementation for prevention of hyperhomocysteinemia in dialysis patients.



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