Clinical applications of Gymnema sylvestre against type 2 diabetes mellitus and its associated abnormalities

Clinical applications of Gymnema sylvestre against type 2 diabetes mellitus and its associated abnormalities

Authors

  • Dhananjay Yadav Department of Medical Biotechnology, Yeungnam University, Gyeongbuk, Republic of Korea
  • Minseok Kwak Department of Chemistry, Pukyong National University, Busan, Republic of Korea
  • Jun-O Jin Department of Medical Biotechnology, Yeungnam University, Gyeongbuk, Republic of Korea; 3Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, China

Keywords:

Diabetes Mellitus, Gymnema sylvestre, Anti-diabetic, Anti-hyperlipidemic, Anti-inflammatory, Anti-Cancerous

Abstract

Diabetes mellitus (Madhumeha) is one of the leading metabolic disorder prevalent in the developing countries which is characterized by high blood sugar level and is associated with macrovascular and microvascular complications. The Indian Ayurveda describes several herbs for the management and treatment of diabetes mellitus among which Gymnema sylvestre (Asclepiadaceae) is revered as a potential antidiabetic herbal drug which has the capability of simultaneously regenerating β-cell and stimulating insulin secretion. Gymnema sylvestre also possesses anti-obesity, anti-hyperlipidemic, anti-inflammatory, and anti-cancerous activities. This review updates the recent developments in the experimental studies conducted on the Gymnema sylvestre as an effective remedy for diabetes mellitus evidenced by both animals and human studies. Moreover, this study also discussed the toxicity of Gymnema sylvestre and future challenges in the roadmap of formulation for prevention and control of diabetes.

Author Biographies

Minseok Kwak, Department of Chemistry, Pukyong National University, Busan, Republic of Korea

Department of Chemistry, Pukyong National University, Busan, 48513, Republic of Korea; Tel: +82-51-629-5595; Fax: +82-51-629-5583; Email: [email protected]

Jun-O Jin, Department of Medical Biotechnology, Yeungnam University, Gyeongbuk, Republic of Korea; 3Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, China

Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 712-749, Republic of Korea; Tel: +82-53-810-3033; Fax: +82-53-810-4769

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Published

05-06-2019

Issue

Vol. 21 No. 2 (2019)

Section

Reviews

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

1.
Yadav D, Kwak M, Jin J-O. Clinical applications of Gymnema sylvestre against type 2 diabetes mellitus and its associated abnormalities. Progr Nutr [Internet]. 2019 Jun. 5 [cited 2025 Mar. 4];21(2):258-69. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/7780
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