Protective effects of camel milk and vitamin E against monosodium glutamate induced biochemical and testicular dysfunctions

Protective effects of camel milk and vitamin E against monosodium glutamate induced biochemical and testicular dysfunctions

Authors

  • Hanan Basiouni Ismail El-Sawy 1Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt
  • Mohamed Mohamed Soliman Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736, Egypt; Medical Laboratories Department, College of Applied Medical Sciences, Taif University, Turabah 311, Saudi Arabia
  • Samir Ahmed El-Shazly Department of Biochemistry, Faculty of Veterinary Medicine, KaferElsheikh University, Egypt; Biotechnology Department, College of Science, Taif University, Alhawiya, Saudi Arabia
  • Hussein Abdel-Maksoud Ali Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736, Egypt

Keywords:

Monosodium glutamate, camel milk, protection, testicular dysfunction, gene expression, Vitamin E.

Abstract

Objective: The current study was outlined to examine the protective effects of camel milk (CM) against the deleterious effects induced by monosodium glutamate (MSG). Methods: MSG was administered either alone or in combination with camel milk or vitamin E for 4 weeks. Serum and testicular tissues were examined using semiquantitative RT-PCR analysis. Results: CM normalized the decrease in serum levels of testosterone, luteinizing hormone (LH), sperm profiles and testicular antioxidant activities that were decreased by MSG. At the molecular levels, MSG down-regulated the mRNA expression of steroidogenesis related genes and receptors of androgen, LH and follicle stimulating hormone. MSG induced testicular apoptosis. All altered genes were normalized and upregulated in presence of CM when compared to the effect of Vit. E. Conclusions: The usage of camel milk as a therapy against MSG used in food industry is very indicative and protective.

Author Biography

Mohamed Mohamed Soliman, Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736, Egypt; Medical Laboratories Department, College of Applied Medical Sciences, Taif University, Turabah 311, Saudi Arabia

Biochemistry

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Published

29-03-2018

Issue

Vol. 20 No. 1 (2018)

Section

Original articles

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
El-Sawy HBI, Soliman MM, El-Shazly SA, Abdel-Maksoud Ali H. Protective effects of camel milk and vitamin E against monosodium glutamate induced biochemical and testicular dysfunctions. Progr Nutr [Internet]. 2018 Mar. 29 [cited 2025 Mar. 4];20(1):76-85. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/5870
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