Short-term feeding with high fructose diet impairs bone mineralization in growing rats

Angelika Manterys; Agnieszka Filipiak-Florkiewicz; Adam Florkiewicz; Magdalena Franczyk-Zarow; Edyta Kus; Marek Sady; Renata B. Kostogrys

doi:10.23751/pn.v20i1-S.5790

Short-term feeding with high fructose diet impairs bone mineralization in growing rats

Authors

Angelika Manterys Department of Human Nutrition, Faculty of Food Technology, University of Agriculture in Cracow
Agnieszka Filipiak-Florkiewicz Department of Nutrition Technology and Consumption, Faculty of Food Technology, University of Agriculture in Cracow
Adam Florkiewicz Department of Nutrition Technology and Consumption, Faculty of Food Technology, University of Agriculture in Cracow
Magdalena Franczyk-Zarow Department of Human Nutrition, Faculty of Food Technology, University of Agriculture in Cracow
Edyta Kus Jagiellonian Centre of Experimental Therapeutics, Jagiellonian University
Marek Sady Department of Animal Product Technology, Faculty of Food Technology, University of Agriculture in Cracow
Renata B. Kostogrys Department of Human Nutrition, Faculty of Food Technology, University of Agriculture in Cracow

Keywords:

high fructose diet, bone mineralization, calcium homeostasis, rats

Abstract

Aim: The objective of this study was to investigate effects of short-term, high fructose intake on mineralization and biomechanical strength of bones in growing rats. Methodology: Male Wistar rats (aged 8 weeks) were divided into two experimental groups. Animals were fed with AIN 93G diet or high fructose diet, containing 63 wt% of fructose, for four weeks. Bone calcium and phosphorus content were determined according to PN-EN 15505:2009 norm and AOAC 986.24-1988 method, respectively. The bones biomechanical strength was tested using texture analyzer. Results: Feeding rats with high fructose diet resulted in significant (p<0,05) decrease of calcium content in femur and tibia. Also phosphorus content was significantly (p<0,05) decreased in femoral bone from animals fed high fructose diet. The biomechanical strength of femur and tibia was slightly lower in high fructose group compared to control. Conclusion: Short-term high fructose intake impairs calcium and phosphorus bone deposition in growing animals.

Downloads

Published

10-07-2018

Issue

Vol. 20 No. 4 (2018)

Section

Original articles

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Manterys A, Filipiak-Florkiewicz A, Florkiewicz A, Franczyk-Zarow M, Kus E, Sady M, et al. Short-term feeding with high fructose diet impairs bone mineralization in growing rats. Progr Nutr [Internet]. 2018 Jul. 10 [cited 2025 Mar. 9];20(4):629-34. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/5790

Download Citation