Efficacy of morin on serum and heart tissue lipids in rats subjected to isoproterenol-induced myocardial injury

Abstract

Lipids and lipoproteins play an important role in the pathology of myocardial infarction. In our early study shows, pretreatment with morin, a flavonoid, ameliorates cardiac markers, adenosine triphosphata­ses and glycoprotein’s in isoproterenol (ISO) induced myocardial infarction in rats at the optimum dose of 40 mg/kg BW. The present study evaluated the flavonoid-morin on lipid profiles in isoproterenol (ISO) induced myocardial infarction in rats. Male albino Wistar rats were pretreated with morin at the optimum dose of 40 mg/kg daily for a period of 30 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected in rats at an interval of 24 h for 2 days. ISO caused a significant increase in the activity of total cholesterol (TC), cholesterol ester (CE), free cholesterol (FC), triglycerides (TG), free fatty acids (FFA) and phospholipids (PL), low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholesterol (VLDL-C) in serum and decreased activities in heart phospholipids, serum high density lipoprotein-cholesterol (HDL-C) levels. Pre-treatment with morin at 40 mg/kg dose blocked these changes to normality which proved their antihyperli­pidemic action. These findings provided evidence that morin was found to be protecting the myocardium against ischemic insult and the protective effect could attribute to its antihyperlipidemic activities.