Evaluation of the efficacy and absorption of a nutraceutical product: pilot study

Main Article Content

Laura Tomaino
Francesca Gori
Cinzia Dellanoce
Alessandra Piontini
Maria Rosaria Ingenito
Vittoria Di Donna
Filomena Napolitano
Vincenzo Soresi
Luisella Vigna
Andrea Fratter

Keywords

antioxidant, aging, oxidative stress, skin aging, coenzyme Q10

Abstract

Background and aim: Oxidative stress is a process involved in aging and numerous human pathologies. The aim of this study was to evaluate the safety and efficacy of MITOFAST® in increasing the levels of markers linked to oxidative stress in plasma and red blood cells of healthy subjects


Methods: Prospective pilot study conducted on 22 healthy adult subjects. All participants received two sachets/day for 30 days of a commercial supplement containing a blend of antioxidant micronutrients (Coenzyme Q10, resveratrol, vitamin C, folic acid, and N-acetylcysteine). At enrolment (T0) and after 4 weeks (T1), blood samples were taken to evaluate homocysteine, gluthatione, coenzyme Q10, cysteinylglycine, cysteine, vitamin C, and vitamin E. Furthermore, any side effects reported by the subjects were evaluated. P-value <0.05 was considered statistically significant.


Results: Vitamin E, coenzyme Q10, and total plasma gluthatione levels significantly increased, whereas vitamin C remained constant after treatment. Homocysteine concentration decreased due to folic acid content (p= 0.003).


Conclusions: The overall increase in the levels of antioxidant molecules measured, together with the reduction of cysteinylglycine and homocysteine, indicate an antioxidant activity of MITOFAST®


 


 

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