Alternative therapeutic applications used in the treatment of ulcerative colitis: probiotics, prebiotics, synbiotics and fecal microbiota transplantation

Main Article Content

Mehmet Çavdar https://orcid.org/0000-0003-3254-0952
Meliha Çavdar https://orcid.org/0000-0001-5122-7860

Keywords

Ulcerative colitis, Inflammatory bowel disease, Probiotic, Prebiotic, Synbiotic, Fecal Microbiota Transplantation

Abstract

Background: Recently, some new generation therapeutic applications that can be used as an alternative to routine pharmacological agents in the treatment of ulcerative colitis (UC) have emerged. These applications are using of probiotics, prebiotics, synbiotics, and fecal microbiota transplantation. Objective: In this review, these therapeutic applications, which have the potential to be used as an alternative to pharmacological agents in the treatment of UC will be investigated. Results: Probiotic supplements are aimed increasing the number of beneficial bacteria in the intestinal microbiota composition, prebiotic supplements support the development of probiotics, and synbiotic supplements combine the positive metabolic effects of both prebiotic and probiotic supplements. Fecal microbiota transplantation (FMT) is used to correct dysbiosis in UC. In studies in the literature, we observed that all these applications generally mediate the improvement of the clinical remission levels of patients with UC, strengthening of the intestinal barrier mechanism, changing of the metabolic parameters of the inflammation picture positively, and the attainment of a healthier composition of the intestinal microflora. Conclusions: Alternative therapeutic applications used in the treatment of UC have been shown to have positive metabolic results on the clinical course of the disease. However, because there is no scientific consensus on the form, duration and content of such applications, further comprehensive studies should be conducted on the subject. Thus, the potential of using probiotic, prebiotic, synbiotic supplements and FMT as an alternative therapeutic application in the treatment of UC will be revealed more clearly.

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