The Progressive Reduction of Cholesterol: Does it Open a Way to Psychopathology?

Main Article Content

Massimo Cocchi

Keywords

cholesterol, biochemical dynamics of life

Abstract

The purpose of this commentary is to highlight the valuable role of Cholesterol in the biochemical dynamics of life. Some curious characteristics of the relationship between Cholesterol and Linoleic Acid are highlighted, not only, as widely documented in humans, but also in different animals such as, for example, bees. In summary, the excessive reduction of Cholesterol could have a disastrous impact on the predisposition to psychopathology, even in its most serious manifestations such as suicide.

Abstract 192 | PDF Downloads 157

References

1. Popper KR. Conjectures and Refutations: The Growth of Scientific Knowledge, London: Routledge 1963; 10, VI: 222.
2. Cholesterol Treatment Trialists’ Collaboration. Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials. Lancet 2019; 393: 407–15.
3. Cocchi M, Tonello L, Gabrielli F. Cholesterol on Sunset Boulevard: the decline of a myth. BMJ Open published online June 29, 2016.
4. Ravnskov U, Diamond DM, Hama R et al. Lack of an association or an inverse association between low-density lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open 2016; 6: e010401.
5. Kristensen ML, Christensen PM, Hallas J. The effect of statins on average survival in randomised trials, an analysis of end point postponement. BMJ Open 2015; 5: e007118.
6. Alvarez JC, Cremniter D, Lesieur P et al. Low Blood Cholesterol and Low Platelet Serotonin Levels in Violent Suicide Attempters. BIOL PSYCHIATRY 1999; 45:1066–1069.
7. Plana T, Gracia R, Méndez I. et al. Total serum cholesterol levels and suicide attempts in child and adolescent psychiatric inpatients. Eur Child Adolesc Psychiatry 2010; 19: 615–619.
8. Benedetti S, Bucciarelli S, Canestrari F et al. Platelet’s Fatty Acids and Differential Diagnosis of Major Depression and Bipolar Disorder through the Use of an Unsupervised Competitive-Learning Network Algorithm (SOM). Open Journal of Depression 2014; 3: 52-73.
9. Cocchi M, Minuto C, Tonello L et al. Linoleic acid: Is this the key that unlocks the quantum brain? Insights linking broken symmetries in molecular biology, mood disorders and personalistic emergentism. BMC Neurosci 2017; 18:38.
10. Cocchi M, Lercker G, Frega NG, Quaranta M. Is a low concentration of Linoleic Acid related to the extended longevity of the Queen honeybee? Progress in Nutrition 2019; .21, 4: 729-734.
11. Cheng-Yen Lu, Po-Jung Huang, Chin-Yuan Hsu. The cholesterol-hydroxyecdysone-vitellogenin pathway is involved in the longevity of trophocytes and oenocytes of queen honey bees (Apis mellifera). Apidologie, Springer Verlag 2018; 49 (6): 721-733
12. Cocchi M, Tonello L. “Bio molecular considerations in Major Depression and Ischemic Cardiovascular Disease”. Central Nervous System Agents in Medicinal Chemistry 2010; 9: 2-11.
13. Cocchi M, Tonello L, Gabrielli F. The Suicide Attempt in an Artificial Neural Network (Self Organizing Map). J Neurol Psychol 2016; 4(2): 7

Most read articles by the same author(s)