Evaluating of aerobic exercise induced metabolic stress on serum asprosin levels: comparison of fitness status Asprosin and exercise

Main Article Content

Sermin Algul
Gulnihal Deniz
Hamit Hakan Alp
Seda Uğraş
Oguz Ozcelik

Keywords

Asprosin, Creatine Kinase, Exercise, Malondialdehyde, Metabolism

Abstract

We comparatively evaluated effects of aerobic exercise performed morning and afternoon on asprosin levels in young trained, sedentary males.


A total of fifty male subjects (trained n=25, 19.2±0.9 years; sedentary n=25, 19.3±1.2 years) participated in morning and afternoon aerobic running exercises to approximately 70% of the subject’s maximal heart rate for about 45 min. Pre- and post-exercise venous blood samples were taken and analysed for asprosin using ELISA. Serum CK and MDA levels were determined by measuring with an autoanalysers and a HPLC, respectively. Paired samples, independent samples t-tests and Pearson correlation analysis were used to analyse data for statistically significance between obtained data.


Asprosin, CK and MDA levels increased significantly at the end of both morning (p<0.05), and afternoon (p<0.05) exercises in the trained and sedentary group. At the end of the acute running exercise in the trained group in the morning, the asprosine, MDA and CK levels increased by 24%, 29% and 32%; while they increased by 24%, 30%, and 40% in the afternoon, respectively. In the sedentary group, asprosin, MDA and CK levels increased by 31%, 38% and 31% after the acute running exercise in the morning, while the asprosin, MDA and CK levels increased by 34%, 58% and 42% after the acute running exercise in the afternoon, respectively.


Asprosine levels were found to be markedly increased in all subjects in both aerobic exercise tests without correlating increase of MDA and CK. Altered asprosin levels could be related other factors rather than metabolic and muscular stress parameters.

Downloads

Download data is not yet available.
Abstract 97 |

References

Algul, S., Ozdenk, C., Ozcelik, O. (2017). Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects. Biology of Sport, 34, 339-344.
Algul, S., Ugras, S., Kara, M. (2018). Comparative evaluation of MDA levels during aerobic exercise in young trained and sedentary male subjects. Eastern Journal of Medicine, 23, 98-101.
American College of Sports Medicine (ACSM). (2014). Guidelines for Exercise Testing and Prescription (9th ed.). Baltimore, MD: Lippincott, Williams and Wilkins.
Berriel, G. P., Costa, R. R., da, Silva, E. S., Schons, P., de, Vargas, G. D., Peyré-Tartaruga, L. A., Kruel, L. F. M. (2020). Stress and recovery perception, creatine kinase levels, and performance parameters of male volleyball athletes in a preseason for a championship. Sports Medicine – Open, 6, 26.
Blundell, J. E., Gibbons, C., Caudwell, P., Finlayson, G., Hopkins, M. (2015). Appetite control and energy balance: impact of exercise. Obesity Reviews, 16, 67-76.
Brancaccio, P., Limongelli, F. M., Maffulli, N. (2006). Monitoring of serum enzymes in sport. British Journal of Sports Medicine, 40, 96-97.
Brancaccio, P., Maffulli, N., Limongelli, F. M. (2007). Creatine kinase monitoring in sport medicine. British Medical Bulletin, 81-82, 209-230.

Ceylan, H. I., Saygın, Ö., Türkcü, Ö. Ü. (2020). Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men. Chronobiology International, 37, 1252-1268.
Church, T. (2011). Exercise in obesity, metabolic syndrome, and diabetes. Progress in Cardiovascular Diseases, 53, 412-418.
Duerrschmid, C., He, Y., Wang, C., Li, C., Bournat, J. C., Romere, C., Saha, P. K., Lee, M. K., Phillips, K. J., Jain, M., Jia, P., Zhao, Z., Farias, M., Wu, Q., Milewicz, D. M., Sutton, V. R., Moore, D. D., Butte, N. F., Krashes, M. J., Xu, Y., Chopra, A. R. (2017). Asprosin is a centrally acting orexigenic hormone. Nature Medicine, 23, 1444-1453.
Hazell, T. J., Islam, H., Townsend, L. K., Schmale, M. S., Copeland, J. L. (2016). Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: potential mechanisms. Appetite, 98, 80–88.
Hoffmann, J. G., Xie, W., Chopra, A. R. (2020). Energy regulation mechanism and therapeutic potential of asprosin. Diabetes, 69, 559-566.
Howley, J. A., Holloszy, J. (2009). Exercise: it's the real thing!. Nutrition Review, 67, 172-178.
7) Kränkel, N., Bahls, M., Van, Craenenbroeck, E. M., Adams, V., Serratosa, L., Solberg, E. E., Hansen, D., Dörr, M., Kemps, H. (2019). Exercise training to reduce cardiovascular risk in patients with metabolic syndrome and type 2 diabetes mellitus: How does it work? European Journal of Preventive Cardiology, 26, 701-708.
Kirwan, J. P., Sacks, J., Nieuwoudt, S. (2017). The essential role of exercise in the management of type 2 diabetes. Cleveland Clinic Journal of Medicine, 84, 15-21.
Koch, A. J., Pereira, R., Machado, M. (2014). The creatine kinase response to resistance exercise. Journal of Musculoskeletal and Neuronal Interactions, 14, 68-77.
Ko, J. R., Seo, D. Y., Kim, T. N., Park, S. H., Kwak, H. B., Ko, K. S., Rhee, B. D., Han, J. (2019). Aerobic exercise training decreases hepatic asprosin in diabetic rats. Journal of Clinical Medicine, 8, 666.
Long, W., Xie, X., Du, C., Zhao, Y., Zhang, C., Zhan, D., Li, Z., Ning, Q., Luo, X. (2019). Decreased circulating levels of asprosin in obese children. Hormome Research in Paediatrics, 91, 271–277.
Miller, C. T., Fraser, S. F., Levinger, I., Straznicky, N. E., Dixon, J. B., Reynolds, J., Selig, S. E. (2013). The effects of exercise training in addition to energy restriction on functional capacities and body composition in obese adults during weight loss: A systematic review. PLoS One, 8, 81692.
Mougios, V. (2007). Reference intervals for serum creatine kinase in athletes. British Journal of Sports Medicine, 41, 674-678.
Niki, E. (2014). Biomarkers of lipid peroxidation in clinical material. Biochimica et Biophysica Acta, 1840, 809-817.
Ozcelik, O., Celik, H., Ayar, A., Serhatlioglu, S., Kelestimur, H. (2004). Investigation of the influence of training status on the relationship between the acute exercise and serum leptin levels in obese females. Neuro Endocrinology Letters, 25, 381-385.
Ozcelik, O., Ozkan, Y., Algul, S., Colak, R. (2015). Beneficial effects of training at the anaerobic threshold in addition to pharmacotherapy on weight loss, body composition, and exercise performance in women with obesity. Patient Preference Adherence, 9, 999-1004.
Romere, C., Duerrschmid, C., Bournat, J., Constable, P., Jain, M., Xia, F., Saha, P. K., Solar, M. D., Zhu, B., York, B., Sarkar, P., Rendon, D. A., Gaber, M. W., LeMaire, S. A., Coselli, J. S., Milewicz, D. M., Sutton, V. R., Butte, N. F., Moore, D. D., Chopra, A. R. (2016). Asprosin, a fasting-induced glucogenic protein hormone. Cell, 165, 566–579.
Ross, R., Soni, S., Houle, S. A. (2020). Negative energy balance induced by exercise or diet: effects on visceral adipose tissue and liver fat. Nutrients, 12, 891.
Ugras, S. (2020). Evaluating of altered hydration status on effectiveness of body composition analysis using bioelectric impedance analysis. Libyan Journal of Medicine, 15, 1741904.
Wang, C. Y., Lin, T. A., Liu, K. H., Liao, C. H., Liu, Y. Y., Wu, V. C. C., Wen, M. S., Yeh, T. S. (2019). Serum asprosin levels and bariatric surgery outcomes in obese adults. International Journal of Obesity, 43, 1019-1025.
Wasserman, K., Hansen, J. E., Sue, D. Y., Stringer, W., Whipp, B. J. (2012). Principles of Exercise Testing and Interpretation: Including pathophysiology and clinical applications. 5th Edition. New York, NY, USA: Lippincott Williams & Wilkins.
Wiecek, M., Szymura, J., Maciejczyk, M., Kantorowicz, M., Szygula, Z. (2018). Acute anaerobic exercise affects the secretion of asprosin, irisin, and other cytokines - a comparison between sexes. Frontiers in Physiology, 9, 1782.
Woolf, K., Reese, C. E., Mason, M. P., Beaird, L. C., Tudor-Locke, C., Vaughan, L. A. (2008). Physical activity is associated with risk factors for chronic disease across adult women's life cycle. Journal of the American Dietetic Association, 108, 948-959.
Yuan, M., Li, W., Zhu, Y., Yu, B., Wu, J. (2020). Asprosin: A novel player in metabolic diseases. Frontiers in Endocrinology (Lausanne), 11, 64.
Zhang, Z., Tan, Y., Zhu, L., Zhang, B., Feng, P., Gao, E., Xu, C., Wang, X., Yi, W., Sun, Y. (2009). Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1/2-SOD2 pathway. Life Science, 231, 116554.