Effects of Early Enteral Nutrition Combined with Probiotics on Inflammatory Factors, Nutritional Status, Immune Function and Serum VEGF Expression in Patients with Traumatic Brain Injury

Main Article Content

Fei Wang
Ting Zhang
Guo-guang Lv
Yan Song

Keywords

early enteral nutrition, probiotics, traumatic brain injury, inflammatory factors, nutritional status

Abstract

Objective: To explore the effects of early enteral nutrition combined with probiotics on neurological function, nutrition, inflammation, immune function and serum vascular endothelial growth factor (VEGF) expression in patients with traumatic brain injury (TBI).
Methods: A total of 136 TBI patients treated in our hospital were selected as the objects of study, and randomly divided into control group (n=68) and treatment group (n=68). The patients in control group didn’t take Bifid Triple Viable Enteric-Coated Capsules, while those in treatment group took Bifid Triple Viable Enteric-Coated Capsules. The levels of serum inflammatory factors, T lymphocyte subsets, D-lactic acid, procalcitonin (PCT) and VEGF, and the changes in the Glasgow coma scale (GCS) score for neurological function, nutritional status and immune function were compared in both groups before and after treatment. The incidence of complications was observed in the two groups.
Results: Compared with those before treatment, the levels of serum transferrin (TRF), prealbumin (PA), albumin (ALB), immunoglobulin A (IgA), IgG, IgM, cluster of differentiation 3+ (CD3+), CD4+, CD4+/CD8+ and GCS score significantly rose, while the levels of serum interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), D-lactic acid, PCT, VEGF and CD8+ remarkably declined in the two groups after treatment, and their changes were more obvious in treatment group (p<0.05). The incidence rate of complications was evidently lower in treatment group than that in control group (p<0.05).
Conclusion: Early enteral nutrition combined with probiotics can significantly improve the nutritional status and serum VEGF expression, reduce the inflammatory response and complications, and enhance the immune function in TBI patients, which has important clinical application value.

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