Frailty as a dysruption of steroid “syncrinology” in elderly man

Frailty as a dysruption of steroid “syncrinology” in elderly man

Authors

  • Giorgio Valenti Dipartimento di Medicina Interna e Scienze Biomediche, Sezione di Gerontologia e Geriatria, University of Parma, Parma, Italy

Keywords:

Frailty, sarcopenia, elderly, DHEAS, testosterone

Abstract

In the background of the endocrinological hypothesis of aging, frailty in man can be seen as a dysruption of syncrinology, a term with which we could define the harmonized activity of steroid hormones (DHEAS, cortisol, testosterone). Such endocrine age-related modifications might promote the activation of sarcopenia, which exerts a core position in the progression of frailty in the elderly. Consequently, the use of replacement treatment in order to delay the beginning of such steroid derangement might be a suitable strategy to improve the quality of life of man, whose life length has been significantly extended.

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Published

01-03-2007

Issue

Vol. 78 No. 1Suppl (2007): New frontiers and modelling in neural, endocrine and immune communication

Section

ORIGINAL ARTICLES

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Valenti G. Frailty as a dysruption of steroid “syncrinology” in elderly man. Acta Biomed [Internet]. 2007 Mar. 1 [cited 2024 Jul. 27];78(1Suppl):222-4. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/4622