Investigation of the Effects of Quercetin and Resveratrol Consumption on Lactic Acid Levels and Running Performance of Elite Adolescent Athletics Distance Runners

Main Article Content

Büşra Akkaya
Olcay Salıcı

Keywords

Quercetin, Resveratrol, Sports Performance, Athletics, Lactic Acid, Adolescent Female Athletes, Nutritional Supplements

Abstract

Study Objectives: The aim of this study is to examine the effects of quercetin and resveratrol consumption on lactic acid levels and running performance of elite adolescent athletics distance runners. Methods: Four female and four male adolescent athletes who are interested in elite level athletics participated in the study and the average age of elite adolescent athletes was 16.13 ± 2.03 years, the average body weight of the athletes was 52.02 ± 6.91 kg and their average height was 168.3 ± 10.61 cm. In order to measure athletic performances; in a randomized, single-blind, crossover method used and the study lasted for 3 weeks, one week apart. They were taken to the camp on 2 determined days of each week and placebo supplements were given in the first week, 500 mg quercetin in the second week and 100 mg resveratrol in the third week. They were asked to run 1500 m without supplement on the first day of the camp. Lactic acid measurements were taken before and after the run and running times were recorded. On the second day, the same measurements were repeated with supplements. Paired - T Test was used for the analysis of the obtained data, the level of significance was accepted as 0.05. Results: According to quercetin and resveratrol interventions, only quercetin supplementation made a statistically significant difference in female elite adolescent athletes. However, although not statistically significant, there were differences in running time, which are very important for Track and Field sports. Conclusion: it can be said that this study explains quercetin supplementation decreases lactic acid levels and can provide a better performance by delaying fatigue, especially for female and relatively male athletes.

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References

1. Baysal A. Nutrition. Ankara: Hatiboğlu Publications, 20th Edition; 2012.
2. Dener B. Evaluation of nutritional knowledge level and nutritional status of volleyball players and the effect of nutrition education. Gazi University Institute of Health Sciences Master Thesis; 2018, page 203.
3. Geyer H, Parr MK, Koehler K, Mareck U, Schänzer W, Thevis M. Nutritional supplements cross-contaminated and faked with doping substances. J Mass Spectrom. 2008;43(7):892–902.
4. D’Andrea G. Quercetin: A flavonol with multifaceted therapeutic applications? Fitoterapia. 2015 Oct;106:256–71.
5. Egert S, Wolffram S, Bosy-Westphal A, Boesch-Saadatmandi C, Wagner AE, Frank J, et al. Daily Quercetin Supplementation Dose-Dependently Increases Plasma Quercetin Concentrations in Healthy Humans1. J Nutr. 2008 Sep 1;138(9):1615–21.
6. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, et al. Quercetin, Inflammation and Immunity. Nutrients. 2016 Mar 15;8(3):167.
7. Daneshvar P, Hariri M, Ghiasvand R, Askari G, Darvishi L, Mashhadi NS, et al. Effect of eight weeks of quercetin supplementation on exercise performance, muscle damage and body muscle in male badminton players. Int J Prev Med. 2013;4(May 2014):S53–7.
8. Davis JM, Murphy EA, Carmichael MD. Effects of the dietary flavonoid quercetin upon performance and health. Curr Sports Med Rep. 2009 Jul;8(4):206–13.
9. McAnulty LS, Miller LE, Hosick PA, Utter AC, Quindry JC, McAnulty SR. Effect of resveratrol and quercetin supplementation on redox status and inflammation after exercise. Appl Physiol Nutr Metab. 2013 Jul;38(7):760–5.
10. Freese EC, Trilk JL, Cureton KJ. Effects of Six Weeks of Quercetin Supplementation on Physical Performance in ROTC Cadets. Mil Med. 2010;175(10):791–8.
11. Williams MH. Sports supplements: Quercetin. ACSM’s Heal Fit J. 2011;15(5):17–20.
12. MacRae HSH, Mefferd KM. Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance. Int J Sport Nutr Exerc Metab. 2006 Aug;16(4):405–19.
13. Knutson MD, Leeuwenburgh C. Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutr Rev. 2008 Sep 25;66(10):591–6.
14. Sayın O, Arslan N, Güner G. Resveratrol and the Cardiovascular System. Turkish Biochemistry Journal. 2008;33:117–21.
15. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006 Jun;5(6):493–506.
16. de la Lastra CA, Villegas I. Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochem Soc Trans. 2007 Nov 1;35(5):1156–60.
17. Keser A. Effects of Resveratrol on Adiposity. Five Diy Journal. 2017;45(3):264–72.
18. Wu R-E, Huang W-C, Liao C-C, Chang Y-K, Kan N-W, Huang C-C. Resveratrol protects against physical fatigue and improves exercise performance in mice. Molecules. 2013 Apr 19;18(4):4689–702.
19. Kan N-W, Lee M-C, Tung Y-T, Chiu C-C, Huang C-C, Huang W-C. The Synergistic Effects of Resveratrol combined with Resistant Training on Exercise Performance and Physiological Adaption. Nutrients. 2018 Sep 22;10(10):1360.
20. Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJH. Potential of resveratrol in anticancer and anti-inflammatory therapy. Nutr Rev. 2008 Aug;66(8):445–54.
21. Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, et al. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol. 2007 Nov 1;224(3):274–83.
22. Ergin K, Yaylalı A. A review on resveratrol and its effects. SDU Faculty of Medicine Science Journal. 2013;20(3):115–20.
23. Vieytes MR, Vale-gonza C, Botana LM. Effects of the Marine Phycotoxin Palytoxin on Neuronal pH in Primary Cultures of Cerebellar Granule Cells. J Neurosci Res. 2007;98:90–8.
24. Layne AS, Krehbiel LM, Mankowski RT, Anton SD, Leeuwenburgh C, Pahor M, et al. Resveratrol and exercise to treat functional limitations in late life: Design of a randomized controlled trial. Contemp Clin Trials Commun. 2017;6(2017):58–63.
25. Voduc N, la Porte C, Tessier C, Mallick R, Cameron DW. Effect of resveratrol on exercise capacity: a randomized placebo-controlled crossover pilot study. Appl Physiol Nutr Metab. 2014 Oct;39(10):1183–7.
26. Raj P, Louis XL, Thandapilly SJ, Movahed A, Zieroth S, Netticadan T. Potential of resveratrol in the treatment of heart failure. Life Sci. 2014 Jan 30;95(2):63–71.
27. Dolinsky VW, Jones KE, Sidhu RS, Haykowsky M, Czubryt MP, Gordon T, et al. Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats. J Physiol. 2012 Jun 1;590(11):2783–99.
28. Baltaci SB, Mogulkoc R, Baltaci AK. Resveratrol and exercise. Biomed Reports. 2016;5(5):525–30.
29. Mercken EM, Carboneau BA, Krzysik-Walker SM, de Cabo R. Of mice and men: The benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev. 2012 Jul;11(3):390–8.
30. Narkar VA, Downes M, Yu RT, Embler E, Wang Y-X, Banayo E, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008 Aug 8;134(3):405–15.
31. Hart N, Sarga L, Csende Z, Koltai E, Koch LG, Britton SL, et al. Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food Chem Toxicol. 2013 Nov;61:53–9.
32. Menzies KJ, Singh K, Saleem A, Hood DA. Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. J Biol Chem. 2013 Mar 8;288(10):6968–79.
33. Murase T, Haramizu S, Ota N, Hase T. Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice. Biogerontology. 2009 Aug;10(4):423–34.
34. Kenney WL, Jack HW, David LC. Physiology of Sport and Exercise. Hum Kinet. 2012;418–9.
35. Günay M, Tamer K, Cicioğlu İ. Sports Physiology and Performance Measurement. 3.Print. Ankara: Gazi Bookstore; 2013;3–590 p.
36. Kılınç F. Training and Movement Science Lecture Notes. Isparta: Süleyman Demirel University; 2011.
37. Göktepe M, Günay M. The effect of quercetin administration on exercise , free radical and antioxidant enzym levels. Int J Sci Cult Sport. 2014;(1):775–88.
38. Davis JM, Murphy EA, Carmichael MD, Davis B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1071-7.
39. Dumke CL, Nieman DC, Utter AC, Rigby MD, Quindry JC, Triplett NT, et al. Quercetin’s effect on cycling efficiency and substrate utilization. Appl Physiol Nutr Metab. 2009 Dec;34(6):993–1000.
40. Günay M, Tamer K, Cicioğlu İ. Sports Physiology and Performance Measurement. Ankara: Gazi Bookstore; 2006.
41. Ikai M, Fukunaga T. Calculation of muscle strength per unit cross-sectional area of human muscle by means of ultrasonic measurement. Int Zeitschrift für Angew Physiol Einschließlich Arbeitsphysiologie. 1968;26(1):26–32.
42. Chia M, Lim JM. Concurrent validity of power output derived from the non-motorised treadmill test in sedentary adults. Ann Acad Med Singapore. 2008 Apr;37(4):279–85.
43. Vaiksaar S, Jürimäe J, Mäestu J, Purge P, Kalytka S, Shakhlina L, et al. No effect of menstrual cycle phase on fuel oxidation during exercise in rowers. Eur J Appl Physiol. 2011;111(6):1027–34.
44. Taşkın M, Çelik M.N., Soyal M, Taşkın A.K. The Effect of Regular and Irregular Menstruation on University Students' Claw Force. Kilis 7 Aralik University Physical Education and Sports Science Journal. 2019;3(1):52–8.
45. Wikipedia. 2019 World Championships in Athletics [Internet]. Wikipedia. 2019 [cited 2020 Jun 1]. Available from: https://tr.wikipedia.org/wiki/2019_dunya_Atletizm_Şampiyonası.
46. Kan N-W, Ho C-S, Chiu Y-S, Huang W-C, Chen P-Y, Tung Y-T, et al. Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice. Molecules. 2016 May 18;21(5).
47. Kim HJ, Kim IK, Song W, Lee J, Park S. The synergic effect of regular exercise and resveratrol on kainate-induced oxidative stress and seizure activity in mice. Neurochem Res. 2013;38(1):117–22.