Does MCT1-T1470A Polymorphism Modify Lactate Kinetics and Training Status?
Main Article Content
Keywords
MCT1-T1470A, Polymorphism, Lactate transporters, Anaerobic exercise, Lactate elimination
Abstract
Study Objectives: The (MCT1-T1470A) polymorphism related to monocarboxylate transporters 1 (MCTs) which transport lactate (LA) may affect LA kinetics and training status, which is unclear. Methods: Participants in the athletic group (AG; 42 anaerobic athletes; 21.8 ± 2.7 years) and the control group (CG; 39 sedentary men; 23.0 ± 3.3 years) performed the Yoyo recovery level 1 test. LA elimination speeds were calculated by dividing the difference between LA5, LA15, and LA30 values of passive recovery corresponding to the 5th, 15th, and 30th minutes following the Yoyo test by the elapsed time. MCT1 polymorphism was determined from genomic DNA samples by next-generation sequencing. Results:The LA5, LA15, and LA30 values of the control group were significantly higher than those of the athlete group (p=0.053, p=0.042, and p=0.028, respectively), but not for LA elimination speeds. There was no significant difference for these parameters between genotype groups. Although the VO2max of the AA control group was significantly greater than that of the T carrier (Tc) control group, there was no significant difference for VO2max between the athletic genotype groups (AA and Tc). Conclusions: MCT1-T1470A polymorphism did not have a significant effect on LA kinetics in athletes. However, the AA group was negatively affected for VO2max compared to the Tc group. This may be due to extreme sensitivity of the AA group to the training caused by this polymorphism. Further studies are needed to shed light on this entity.
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Zafer Bilgin, Coaching Education Department, Faculty of Sport Sciences, Celal Bayar University, Manisa, Turkey
Zafer Bilgin (Research assistant)
Faculty of Sport Sciences, Celal Bayar University, Manisa, Turkey
Oya Yigittürk, Department of Sport Health Sciences, Institute of Health Sciences, Ege University, Bornova, Izmir, Turkey
Dr. Oya Yigittürk (PHD, Sports Sciences)
Department of Sport Health Sciences, Institute of Health Sciences, Ege University, Bornova, Izmir, Turkey
Semih Aşıkovalı, Department of Medical Genetics, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
Dr. Semih Aşıkovalı (MD, Medical genetics)
Faculty of Medicine, Medical Genetics Department, Ege University, Bornova, Izmir, Turkey
Ahmet Köksal, Faculty of Sport Sciences, Department of Sports Management Sciences, Ege University, Bornova, Izmir, Turkey
Ahmet Köksal (Research assistant)
Faculty of Sport Sciences, Department of Sports Management Sciences, Ege University, Bornova, Izmir, Turkey
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