Effects of Liraglutide Combined with Low Fat Diet on Neural and Thermogenic Activities of 5' - AMPK in the Hypothalamus: Expectations
Main Article Content
Keywords
Keywords: liraglutide, glucagon like peptide-1 agonist, hypothalamus, Nuroprotective, 5'-AMP-activated protein kinase, thermogenesis, low fat diet, high fat diet, and obesity.
Abstract
Background: Medical nutrition therapy is essential in managing and preventing diseases. Liraglutide is among glucagon-like peptide-1(GLP-1) agonists’ play a critical role in managing weight as they could modulate the effectiveness of 5’ AMP-activated protein kinase (5'-AMPK) in the hypothalamus. Additionally, the neural activity of 5'-AMPK is negatively affected by high-fat diets; and it remains unclear how low-fat diets combined with liraglutide could counteract this effect. Objectives: To investigate the effects of a high-fat diet on the neural and thermogenic activities of 5’ –AMPK in the hypothalamus and the possible effects of combining a low-fat diet with a liraglutide regimen on 5’ –AMPK activity in the hypothalamus. Methods: We searched the available literature for articles published in PubMed, Science Direct, and ClinicaTrials.gov between November/2020 and January /2021, published in 6 years, and we included controlled clinical trials. Findings: A total 108 out of 230 articles included in our search, and findings revealed that high-fat diets negatively influence liraglutide and 5'-AMPK in the hypothalamus. In contrast, a low-fat diet could reverse this negative influence if combined with a dose of 1.8-3 mg/kg of liraglutide for up to 16 weeks. Conclusion: 5'-AMPK stimulates energy production in peripheral tissues, improves metabolic status, and liraglutide controls food intake in the hypothalamus, but high-fat diets counteract previously mentioned effects of liraglutide and 5'-AMPK. We found no adequate studies that adequately examined the effect of a low-fat diet on liraglutide and 5'-AMPK; hence, our concern was reviewing and predicting the possible effect of low-fat diets.
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Mar 28, 2022
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Al-Domi H, Khalil R, Batarseh N. Effects of Liraglutide Combined with Low Fat Diet on Neural and Thermogenic Activities of 5’ - AMPK in the Hypothalamus: Expectations . Progr Nutr [Internet]. 2022 Mar. 28 [cited 2024 Jul. 18];24(1):e2022003. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/11502
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Author Biographies
Hayder Al-Domi, The university of Jordan
Professor of Nutrition and Dietetics,
Department of Nutrition and Food Technology
School of Agriculture
Raida Khalil, Philadelphia University, Amman
Assoc. Prof. of Biotechnology and Genetics Engineering
Department of Biotechnology and Genetics Engineering
School of Science Faculty of Science
Nour Batarseh, The university of Jordan
PhD Candidate
Department of Nutrition and Food Technology
School of Agriculture
How to Cite
1.
Al-Domi H, Khalil R, Batarseh N. Effects of Liraglutide Combined with Low Fat Diet on Neural and Thermogenic Activities of 5’ - AMPK in the Hypothalamus: Expectations . Progr Nutr [Internet]. 2022 Mar. 28 [cited 2024 Jul. 18];24(1):e2022003. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/11502
