Predictive factors of volumetric reduction in lumbar disc herniation treated by O2-O3 chemiodiscolysis

Alberto Negro; Aldo Paolucci; Camilla Russo; Martina Di Stasi; Pasquale Guerriero; Francesco Arrigoni; Federico Bruno; Francesco Pagnini; Salvatore Alessio Angileri; Pierpaolo Palumbo; Carlo Masciocchi; Gianfranco Puoti; Fabio Tortora; Ferdinando Caranci

doi:10.23750/abm.v91i8-S.9975

Predictive factors of volumetric reduction in lumbar disc herniation treated by O2-O3 chemiodiscolysis

Authors

Alberto Negro Ospedale del Mare – ASL NA1, Neuroradiology Unit,Dipartimento di Scienze Mediche, Chirurgiche, Neurologiche, Metaboliche e dell’invecchiamento, University of Campania “Luigi Vanvitelli”, Naples, Italy
Aldo Paolucci Ospedale Maggiore Policlinico Milano, Milan, Italy
Camilla Russo Advanced Biomedical Sciences Department University of Naples “Federico II”, Napoli, Italy
Martina Di Stasi Advanced Biomedical Sciences Department University of Naples “Federico II”, Napoli, Italy
Pasquale Guerriero Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, Campobasso, Italy
Francesco Arrigoni Department of Biotechnology and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
Federico Bruno Department of Biotechnology and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
Francesco Pagnini Department of Medicine and Surgery, Unit of Radiology, University of Parma, Parma, Italy.
Salvatore Alessio Angileri Operative Unit of Radiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan University, Via Francesco Sforza, 35, 20122, Milan, Italy.
Pierpaolo Palumbo Department of Biotechnology and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
Carlo Masciocchi Department of Biotechnology and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
Gianfranco Puoti Second Division of Neurology. Department of Advanced Medical and Surgical Sciences, Universityof Campania “Luigi Vanvitelli”, Naples, Italy
Fabio Tortora Advanced Biomedical Sciences Department University of Naples “Federico II”, Napoli, Italy
Ferdinando Caranci Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy

DOI: https://doi.org/10.23750/abm.v91i8-S.9975

Keywords:

Lumbar Disc Herniation; Magnetic Resonance Imaging; Chemiodiscolysis; Minimally Invasive Surgery; Oxygen-Ozone Therapy.

Abstract

Purpose: Aim of this study is to assess the effectiveness of O₂-O₃percutaneous chemiodiscolysis by evaluating volumetric changes in lumbar disc herniation on magnetic resonance imaging, in order to identify possible pre-treatment factors affecting such changes Methods: Between January 2014 and December 2017, a total of 87 patients with low back pain and 103 lumbar disc herniations with MRI confirmation were considered for O₂-O₃chemiodiscolysis. The volume of each herniated disc was determined before and after the treatment. Results: Multiple linear regression analysis showed a strong correlation between post-treatment LDH volume percent change and both pre-treatment LDH volume and pre-treatment EQ-VAS (p<0.05), while age showed only a weak positive correlation with post-treatment LDH volume percent change (p<0.1). No association was found for other factors, such as sex and herniation disc level. Conclusions: In conclusion, age, baseline LDH volume and self-assessed disease severity score could represent three easy accessible outcome predictive parameters to consider when intradiscal O₂-O₃ chemiodiscolysis is envisaged. Better results after intradiscal O₂-O₃ chemiodiscolysis were obtained in older patients with higher pre-treatment LDH volume and low-moderate pre-treatment EQ-VAS.

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