Evaluation of Growth Differentiation  Factor-15 in Patients with or without Coronary Artery Disease: Growth Differentiation Factor-15 in Coronary Artery Disease

Shima Hassanzadeh Daloee; Nima  Nakhaei; Mahdy  Hassanzadeh Daloee; Mahmood  Mahmoodi; Maral  Barzegar-Amini

doi:10.23750/abm.v92i2.9267

Evaluation of Growth Differentiation Factor-15 in Patients with or without Coronary Artery Disease

Growth Differentiation Factor-15 in Coronary Artery Disease

Authors

Shima Hassanzadeh Daloee Division of Cardiovascular Medicine, Vascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Nima Nakhaei Division of Cardiovascular Medicine, Vascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mahdy Hassanzadeh Daloee Division of Cardiovascular Medicine, Vascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmood Mahmoodi Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Maral Barzegar-Amini Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

DOI: https://doi.org/10.23750/abm.v92i2.9267

Keywords:

Growth differentiation factor-15, Coronary artery disease, Angiography

Abstract

Background: Growth-differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor-beta cytokine superfamily expressed in human atherosclerotic plaque macrophages. In this study, we sought to compare GDF-15 between patients with coronary artery disease and control group.

Methods: In this cross-sectional study, 176 subjects were enrolled, consisted of 88 coronary artery disease patients (CAD group) and 88 non-CAD participants (control group. Clinical and demographic data, comprising of family history of CAD, history, and lifestyle factors, hypertension, diabetes, and some blood parameters (e.g. glucose, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)), triglyceride, high-sensitivity C-reactive protein (hs-CRP)).

Results: Mean age of the patients was 55.5±11.1 years (age range: 28–80 years). Of all the participants, 91 (51.7%) were male and 85 (48.3%) female. Hs-CRP, LDL-C, and GDF-15 levels were significantly higher in the CAD patients (P=0.091, P=0.008, and P<0.001, respectively). Total cholesterol, hematocrit, and hemoglobin were significantly higher in the controls (P=0.002, P=0.011, and P=0.055, respectively). The area under the receiver operating characteristic curve yielded the satisfactory result of 0.9 (95% CI, 0.8-0.9; P<0.001). The optimum cut-off value of GDF-15 was 1233 ng/L with 71% specificity and 71% sensitivity for CAD diagnosis.

Conclusion: These data suggest that serum GDF-15 might be useful in prediction of CAD.

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