Contact dermatitis due to transdermal therapeutic systems: a clinical update

Paolo Romita; Caterina Foti; Gianfranco Calogiuri; Stefania Cantore; Andrea Ballini; Gianna Dipalma; Francesco Inchingolo

doi:10.23750/abm.v90i1.6563

Contact dermatitis due to transdermal therapeutic systems: a clinical update

Authors

Paolo Romita Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Italy http://orcid.org/0000-0002-5559-9722
Caterina Foti Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari Aldo Moro, Bari, Italy
Gianfranco Calogiuri IV Department of Pneumology and Allergy, Civil Hospital Sacro Cuore, Gallipoli (Lecce), Italy
Stefania Cantore Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Andrea Ballini Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Gianna Dipalma Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Francesco Inchingolo Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy

DOI: https://doi.org/10.23750/abm.v90i1.6563

Keywords:

allergic contact dermatitis, drugs, excipients, rubber, transdermal therapeutic systems

Abstract

Transdermal therapeutic systems (TTS) have become a popular method of drug delivery because they allow drugs to be delivered in a rate-controlled manner, avoiding first-pass metabolism and the fluctuating plasma concentrations encountered with oral medications. Unfortunately, TTS may provoke adverse skin reactions as irritating contact dermatitis and allergic contact dermatitis: TTS seem to be ideally suited to produce sensitization because they cause occlusion, irritation, due to the repeated placement of the allergen in the same skin location. Since TTS consist of an adhesive, an active pharmaceutical drug and enhancing agents, sensitization may develop owing to one of these three agents. The purpose of this manuscript is to review known responsible allergens of contact dermatitis due to TTS.

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Published

26-10-2018

Issue

Vol. 90 No. 1 (2019)

Section

REVIEWS

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

Romita P, Foti C, Calogiuri G, et al. Contact dermatitis due to transdermal therapeutic systems: a clinical update. Acta Biomed. 2018;90(1):5-10. doi:10.23750/abm.v90i1.6563

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