Aerosolized hyaluronic acid and its applications

Aerosolized hyaluronic acid and its applications

Authors

  • V. Raia Department of Translational Medical Sciences University “Federico II” of Naples, Italy
  • A. Sepe Department of Translational Medical Sciences University “Federico II” of Naples, Italy
  • A. Tosco Department of Translational Medical Sciences University “Federico II” of Naples, Italy
  • F. De Gregorio Department of Translational Medical Sciences University “Federico II” of Naples, Italy
  • F. Amato Department of Translational Medical Sciences University “Federico II” of Naples, Italy

Keywords:

hyaluronic acid, respiratory disease, inhaled therapy

Abstract

Although the interaction of low MW HA fragments with surface receptors such as TLRs may explain how HA can favor the inflammatory response, some physical and chemical properties, such as high MW HA, may increase its capability to retain water and to preserve the distensibility of elastic fibers that is dependent on the interaction with water molecules, thus enhancing pulmonary ventilation. Encouraging clinical results provide the beneficial effect of inhaled HA in CF patients who have previously shown poor tolerance to aerosolized hypertonic saline solution.

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Issue

Vol. 85 No. 4 (2014): Supplement: Inhalation therapy in cystic fibrosis

Section

ORIGINAL ARTICLES

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Raia V, Sepe A, Tosco A, De Gregorio F, Amato F. Aerosolized hyaluronic acid and its applications. Acta Biomed [Internet]. 2014 Dec. 9 [cited 2024 Jul. 27];85(4):22-5. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/4084