Efficacy of NaCl nebulized hypertonic solutions in cystic fibrosis

Efficacy of NaCl nebulized hypertonic solutions in cystic fibrosis

Authors

  • A. Manca Azienda Ospedaliero Universitaria “Policlinico”, DAI Scienze e Chirurgia Pediatriche, Centro Regionale Pugliese Specializzato di Riferimento per la Fibrosi Cistica, Bari
  • V. Difino Azienda Ospedaliero Universitaria “Policlinico”, DAI Scienze e Chirurgia Pediatriche, Centro Regionale Pugliese Specializzato di Riferimento per la Fibrosi Cistica, Bari
  • F. Urbano Azienda Ospedaliero Universitaria “Policlinico”, DAI Scienze e Chirurgia Pediatriche, Centro Regionale Pugliese Specializzato di Riferimento per la Fibrosi Cistica, Bari

Keywords:

hypertonic saline, CFTR, inhalation therapy, cystic fibrosis

Abstract

Introduction: CFTR deficiency produces poor water secretions. We studied the effects of nebulized hypertonic solution. Methods: 30 CF patients, each patient considered a control of himself, were followed to evaluate the therapeutic efficacy by spirometric indices. Outcomes: Results, statistically significant, indicate best results for small/medium airways. Conclusion: Nebulized hypertonic saline achieves the best results in heterozygous F508del, BCC negative, BMI>5th

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Issue

Vol. 85 No. 4 (2014): Supplement: Inhalation therapy in cystic fibrosis

Section

ORIGINAL ARTICLES

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Manca A, Difino V, Urbano F. Efficacy of NaCl nebulized hypertonic solutions in cystic fibrosis. Acta Biomed [Internet]. 2014 Dec. 9 [cited 2024 Jul. 27];85(4):10-8. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/4082