Cefepime for prophylaxis of infections in the surgery of cholelithiasis. Results of a multicentric comparative trial

Cefepime for prophylaxis of infections in the surgery of cholelithiasis. Results of a multicentric comparative trial

Authors

  • P. Del Rio
  • M. Vellone
  • P. Fragapane, et al.

Keywords:

Antimicrobial prophylaxis, biliary tract surgery, cholecystectomy, Cefepime, Ceftriaxone

Abstract

A multicenter, open labelled, randomized study was carried out to compare the prophylactic efficacy of Cefepime and Ceftriaxone in patients undergoing biliary tract surgery. Two hundred and nine patients were included in the study and randomized to receive preoperative infusion of 2 g Cefepime (n=107) or 2 g Ceftriaxone (n=102) both in a single i.v. administration. Antimicrobial prophylaxis was successful in preventing infections in 98.9% of patients in the Cefepime group and 97.7% in the Ceftriaxone group (p=0.3871). Both regimens were well tolerated without any adverse drug-related reactions. A single dose of Cefepime seems to be a very useful alternative to other regimens for antibiotic prophylaxis of postoperative infectious complications in the elective surgical treatment of cholelithiasis.

Downloads

Published

01-04-2008

Issue

Vol. 79 No. 1 (2008)

Section

ORIGINAL ARTICLES

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Transfer of Copyright and Permission to Reproduce Parts of Published Papers. 
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.

How to Cite

1.
Del Rio P, Vellone M, Fragapane, et al. P. Cefepime for prophylaxis of infections in the surgery of cholelithiasis. Results of a multicentric comparative trial. Acta Biomed [Internet]. 2008 Apr. 1 [cited 2024 Jul. 27];79(1):23-7. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/1854