Evaluation of oxidative stress among coronary diabetics patients
Keywords:
Glutathione peroxidase [GPX], total antioxidant status [TAS], high sensitivity C reactive protein (hs-CRP), cardiovascular diseases, diabetesAbstract
Abstract. Objectives: Determination of the superoxide dismutase (SOD), glutathione peroxidase (GPX) and the total antioxidant status (TAS) and evaluation of inflammation by the use of high sensitivity C reactive protein (hs-CRP) among Tunisian coronary diabetic patients. Materials and methods: We measured the erythrocyte GPX activity and the plasmatic TAS concentration by colorimetric methods, the apolipoproteins [ApoA1, ApoB], hs-CRP and the fibrinogen by immunonephelometry assays. Results: TAS and GPX were significantly decreased among patients compared to the controls [TAS: 1,14 ± 0,28 mmol/l vs 1,55 ± 0,35 mmol/l, GPX: 59,32 ± 10,72 U/gHb vs 149,19 ± 30,95 U/gHb]. For the coronary diabetic patients, the TAS is correlated positively with hs-CRP [r= 0,01, p<10-3]. Pearson’s correlation shows a significantly positive correlation between GPX and TAS among all patients. Conclusions: Determination of antioxidative defense markers contributes to understanding the effect of stress oxidative on the development, prevention and therapy of cardiovascular disease.Downloads
Published
Issue
Section
License
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.