A study to assess the impact of maternal psycho-emotional health on childhood morbidity: a comparative study of ART and natural conception

A study to assess the impact of maternal psycho-emotional health on childhood morbidity: a comparative study of ART and natural conception

Authors

  • Aiman Iskakova Scientific Center of Pediatrics and Pediatric Surgery
  • Lyazat Manzhuova Scientific Center of Pediatrics and Pediatric Surgery
  • Gulnara Iskakova National Scientific Center for Health Development named after Salidat Kairbekova
  • Nazgul Assulkanova Scientific Center of Pediatrics and Pediatric Surgery
  • Kulzhamila Nusipzhanova Scientific Center of Pediatrics and Pediatric Surgery

Keywords:

children, ART, depression, anxiety, respiratory diseases

Abstract

The aim of this study was a longitudinal study to assess the impact of the psycho-emotional state of health of 252 mothers and the level of maternal care on the morbidity rate of acute respiratory infections in children born using assisted reproductive technologies (ART) and by natural conception.  In addition, the effects of prematurity and low birth weight, Apgar scores, breastfeeding, and kindergarten attendance on the incidence of acute upper and lower respiratory tract infections in children in both groups were studied. We compared two comparable groups of healthy children aged 0- to 3 years and their mothers. The mothers' levels of anxiety and depression were determined, as well as the level of parental care for the child, and a personal interview was also conducted.  The children were examined, as well as a history and analysis of medical records. Univariate and multivariate negative binomial regression analysis models were used for statistical analysis to assess the influence of predictors on child morbidity rates. The incidence of respiratory tract infections was significantly lower in the ART group. As a result of the study, we did not find a statistically significant effect of maternal anxiety and depression on the incidence of respiratory infections in their children in both groups. Our findings revealed that after the birth of a child, mothers in the ART group took better care of the long-awaited and often only child, which reduced the incidence of the disease in this group. 

References

Berntsen S, Söderström-Anttila V, Wennerholm UB, et al. The health of children conceived by ART: 'The chicken or the egg? Hum Reprod Update. 2019;25(2):137-158. doi: 10.1093/humupd/dmz001.

Adeleye AJ, Zablotska L, Rinaudo P, Huang D, Lustig RH, Cedars MI. Study protocol for a Developmental Epidemiological Study of Children born through Reproductive Technologies (DESCRT). Hum Reprod Open. 2023;2023(2):hoad013. doi: 10.1093/hropen/hoad013.

Chen M, Heilbronn LK. The health outcomes of human offspring conceived by assisted reproductive technologies (ART). Dev Orig Health Dis. 2017;8(4):388–402.doi:10.1017/S2040174417000228.

Luke B, Brown MB, Wantman E, et al. The risk of birth defects with conception by ART. Hum Reprod. 2021;36(1):116-129. doi: 10.1093/humrep/deaa272.

Fortunato A, Tosti E. The impact of in vitro fertilization on health of the children: an update. Eur J Obstet Gynecol Reprod Biol. 2011;154(2):125-9. doi: 10.1016/j.ejogrb.2010.10.012.

Hart R, Norman R J. The longer-term health outcomes for children born as a result of IVF treatment. Part II--Mental health and development outcomes. Hum Reprod Update. 2013;19(3):232-43. doi: 10.1093/humupd/dms062.

Otto C, Reiss F, Voss K, et al. Mental health and well-being from childhood to adulthood: design, methods, and results of the 11-year follow-up of the BELLA study. Euro Child Adolesc Psychiatry. 2021;10:1559-1577. doi: 10.1007/s00787-020-01630-4.

Librach CL. Assisted reproduction involving gestational surrogacy: an analysis of the medical, psychosocial and legal issues: experience from a large surrogacy program. Hum Reprod. 2015;30(2):345-52. doi: 10.1093/humrep/deu333.

Belva F, Bonduelle M, Roelants M, Verheyen G, Van Landuyt L. Neonatal health including congenital malformation risk of 1072 children born after vitrified embryo transfer. Hum Reprod. 2016;31(7):1610-20. doi: 10.1093/humrep/dew103.

Pinborg A, Wennerholm UB, Bergh C. Long-term outcomes for children conceived by assisted reproductive technology. Fertil Steril. 2023;120(3 Pt 1):449-456. doi: 10.1016/j.fertnstert.2023.04.022.

Hack M, Klein NK, Taylor HG. Long-term developmental outcomes of low birth weight infants. Future Child. 1995;5(1):176-96. PMID: 7543353.

McGauhey PJ, Starfield B, Alexander C, Ensminger ME. Social environment and vulnerability of low birth weight children: a social-epidemiological perspective. Pediatrics. 1991;88(5):943-53. PMID: 1945635.

Goldberg S, Perrotta M, Minde K, Corter C. Maternal behavior and attachment in low-birth-weight twins and singletons. Child Dev. 1986;57(1):34-46. doi: 10.1111/j.1467-8624.1986.tb00004.x.

Richter, Linda. World Health Organization. The importance of caregiver-child interactions for the survival and healthy development of young children: a review. WHO Library Cataloguing-in-Publication Data. ISBN 92 4 159134 X (NLM classification: WS 105.5.C3).

Colpin H, Munter AD, Nys K, Vandemeulebroecke L. Parenting stress and psychosocial well-being among parents with twins conceived naturally or by reproductive technology. Hum Reprod.1999;14(12):31337.doi:10.1093/humrep/14.12.3133.

Vilska S, Unkila-Kallio L, Punamäki RL, et al. The mental health of mothers and fathers of twins conceived via assisted reproduction treatment: a 1-year prospective study. Hum Reprod. 2009;24(2):367-77. doi: 10.1093/humrep/den427.

Earls MF, Yogman MW, Mattson G, Rafferty J. Incorporating recognition and management of perinatal depression into pediatric practice. Pediatrics.2019;143(1):e20183259. doi:10.1542/peds.2018-3259.

Kisely, S. Leske S, Arnautovska U, et al. A 40-year study of child maltreatment over the early life course predicting psychiatric morbidity, using linked birth cohort and administrative health data: protocol for the Childhood Adversity and Lifetime Morbidity (CALM) study. BJPsych Open. 2023; 9(2):e50. doi:10.1192/bjo.2023.29.

Sajedi F, Doulabi MA, Vameghi R, Mazaheri MA, Akbarzadehbaghban A. Relationship of Mothers’ Psychological Status with Development of Kindergarten Children. Iran J Child Neurol. 2016;10(3):61-72.PMID: 27375758.

Davenport MH, Meyer S, Meah VL, Morgan CS, Khurana R. Moms Are Not OK: COVID-19 and Maternal Mental Health. Front Glob Womens Health. 2020;19:1:1. doi:10.3389/fgwh.2020.00001.

Oyetunji A, Chandra P. Postpartum stre ss and infa nt outcome: A re view of current literature. Psychiatry Res. 2020;284:112769. DOI:10.1016/j.psychres.2020.112769

Stein A, Gath DH, Bucher J, Bond A, Day A, Cooper PJ. The relationship between post-natal depression and mother-child interaction. Br J Psychiatry. 1991;158:46-52. doi: 10.1192/bjp.158.1.46. PMID: 2015451.

Shalowitz MU, Berry CA, Quinn KA, Wolf RL. The relationship of life stressors and maternal depression to pediatric asthma morbidity in a subspecialty practice. Ambul Pediatr. 2001;1(4):185-93. doi: 10.1367/1539-4409.

Battle DE. Diagnostic and Statistical Manual of Mental Disorders (DSM). Codas. 2013;25(2):191-2. doi: 10.1590/s2317-17822013000200017.

Li YF, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest. 2005;127(4):1232-41. doi: 10.1378/chest.127.4.1232.

Goodwin RD, Wickramaratne P, Nomura Y, Weissman MM. Familial depression and respiratory illness in children. Arch Pediatr Adolesc Med. 2007;161(5):487-94. doi: 10.1001/archpedi.161.5.487.

Weissman MM, Gammon GD, John K, et al. Children of depressed parents. Increased psychopathology and early onset of major depression. Arch Gen Psychiatry. 1987;44(10):847-53. doi: 10.1001/archpsyc.1987.01800220009002.

Drakina SA, Perevoschikova NK. Prophylaxis of respiratory diseases in young children during the period of adaptation to preschool educational institutions. Pediatria. 2019; 98 (1): 122-128. doi: 10.24110/0031-403X-2019-98-1-122-128 (in Russian)

Rudan I, Tomaskovic L, Boschi-Pinto C. Global estimate of the incidence of clinical pneumonia among children under five years of age. Bull World Health Organ. 2004;82(12):895-903. PMID: 15654403.

Murphy TF, Henderson FW, Clyde WA Jr, Collier MA, Denny FW. Pneumonia: an eleven-year study in a pediatric practice. Am J Epidemiol. 1981;113(1):12-21. doi: 10.1093/.aje.a113061.

Bhurtel R, Pokhrel RP, Kalakheti B. Acute Respiratory Infections among Under-five Children Admitted in a Tertiary Hospital of Nepal: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2022; 60(245):17-21. doi:10.31729/jnma.6889.

Kohns Vasconcelos M, Loens K, Sigfrid L, et al. Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study. BMJ Open Respir Res. 2021;8(1):e000887. doi: 10.1136/bmjresp-2021-000887.

Chung FF, Wan GH, Kuo SC, et al. Mother-infant interaction quality and sense of parenting competence at six months postpartum for first-time mothers in Taiwan: a mul tiple time serie s design. BMC Pregna ncy Childbirth. 2018;18(1):365. doi:10.1186/s12884-018-1979-7.

Brummelte S, Galea LA. Postpartum depression: Etiology, treatment and consequences for maternal care. Horm Behav. 2016;77:153-66. doi: 10.1016/j.yhbeh.2015.08.008.

Westrupp EM, Macdonald MA, Bennet C, et al. The Child and Parent Emotion Study: protocol for a longitudinal study of parent emotion socialization and child socioemotional development. BMJ Open. 2020;10(10):e038124. doi: 10.1136/bmjopen-2020-038124.

Westrupp EM, Brown S, Woolhouse H, Gartland D, Nicholson JM. Repeated early-life exposure to inter-parental conflict increases the risk of preadolescent mental health problems. Eur J Pediatr. 2018; 177:419–27.doi:10.1007/s00431-017-3071-0.

Leon, David A, Gill Walt, et al. Children’s health in developing countries: issues of coping, child neglect and marginalization in Poverty, Inequality, and Health: An International Perspective.Oxford:Oxford Academic; 2000; pp. 137-158. doi:10.1093/acprof:oso/9780192631961.003.0007.

Serbin LA, Hubert M, Hastings PD, Stack DM, Schwartzman AE. The influence of parenting on early childhood health and health care utilization. J Pediatr Psychol. 2014;39(10):1161-74. doi: 10.1093/jpepsy/jsu050.

Davis CL, Delamater AM, Shaw KH, La Greca AM, Eidson MS, Perez-Rodriguez JE, Nemery R. Parenting styles, regimen adherence, and glycemic control in 4- to 10-year-old children with diabetes. J Pediatr Psychol. 2001;26(2):123-9. doi: 10.1093/jpepsy/26.2.123.

Morrongiello BA. Caregiver supervision and child-injury risk: I. Issues in defining and measuring supervision; II. Findings and directions for future research. J Pediatr Psychol. 2005;30(7):536-52. doi: 10.1093/jpepsy/jsi041.

Schwebel DC, Brezausek CM. How do mothers and fathers influence pediatric injury risk in middle childhood? J Pediatr Psychol. 2010;35(8):806-13. doi: 10.1093/jpepsy/jsp130.

Lohaus, A., Vierhaus, M., & Ball, J. Parenting styles and health-related behavior in childhood and early adolescence: Results of a longitudinal study. J Earl Adoles. 2009; 29:449–475. doi: 10.1177/0272431608322954.

Arroyo-Borrell E, Renart J, Saurina C, Saez M. Influence maternal background has on children’s mental health. Int J Equity Health. 2017; 16(1). doi:10.1186/s12939-017-0559-1.

Wall-Wieler E, Roos LL, Gotlib IH. Maternal Depression in Early Childhood and Developmental Vulnerability at School Entry. Pediatrics. 2020;146(3):e20200794. doi: 10.1542/peds.2020-0794.

Rowell T, Neal-Barnett A. Systematic Review of the Effect of Parental Adverse Childhood Experiences on Parenting and Child Psychopathology. J Child Adolesc Trauma. 2021;15(1):167-180. doi: 10.1007/s40653-021-00400-x.

Denham SA, Workman E, Cole PM, Weissbrod C, Rendziora KT, Zahn-Waxler C. Prediction of externalizing behavior problems from early to middle childhood: the role of parental socialization and emotion expression. Dev Psychopathol. 2000; 12(1):23–45.doi:10.1017/S0954579400001024.

Eisenberg N, Cumberland A, Spinrad TL. Parental socialization of emotion. Psychol Inq. 1998; 9:241–73.doi:10.1207/s15327965pli0904.1.

Colpin H, Munter AD, Nys K, Vandemeulebroecke L. Parenting stress and psychosocial well-being among parents with twins conceived naturally or by reproductive technology. Hum Reprod. 1999;14(12):3133-7. doi: 10.1093/humrep/14.12.3133.

Vilska S, Unkila-Kallio L. Mental health of parents of twins conceived via assisted reproductive technology. Curr Opin Obstet Gynecol. 2010;22(3):220-6. doi: 10.1097/GCO.0b013e3283384952.

Sydsjö G, Wadsby M, Sydsjö A, Selling KE. Relationship and parenthood in IVF couples with twin and singleton pregnancies compared with spontaneous singleton primiparous couples--a prospective 5-year follow-up study. Fertil Steril. 2008;89(3):578-85. doi: 10.1016/j.fertnstert.2007.03.064.

Morozova MA, Potanin SS, Beniashvili AG, et al. Validaton of the Hospital Anxiety and Depression Scale Russian-language version in the general population. Russ J Prevent Medicine.2023; 26(4):7-14. (in Russian). doi:10.17116/profmed2023260417.

Markovskaya IM. Diagnostics and training of interaction between parents and children. St. Petersburg, 1996. - p. 165-167. The Russian State Library. [in Russian]. -The vault cipher: OD 61 96-19/173-5.

Stern AF. The hospital anxiety and depression scale. Occup Med (Lond). 2014;64(5):393-4. doi: 10.1093/occmed/kqu024.

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Published

28-08-2024

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PEDIATRICS AND ADOLESCENT MEDICINE

How to Cite

1.
Iskakova A, Manzhuova L, Iskakova G, Assulkanova N, Nusipzhanova K. A study to assess the impact of maternal psycho-emotional health on childhood morbidity: a comparative study of ART and natural conception. Acta Biomed. 2024;95(4):e2024126. doi:10.23750/abm.v95i4.15922