Castleman disease: a rare case in a young woman

Castleman disease: a rare case in a young woman

Authors

  • Maria Teresa Paparella
  • Teresa Popolizio
  • Daniela Grasso
  • Ettore Angelo Serricchio
  • Giuseppe Guglielmi

Keywords:

Castleman disease (CD), lymph nodes, unicentric Castleman disease (UCD), excisional biopsy

Abstract

Castleman disease is a rare lymphoproliferative disorder characterized by benign enlargement of lymph nodes. It is divided into unicentric disease, which involves a single enlarged lymph node, and multicentric disease, which affects multiple lymph node stations. In this report, we describe a rare case of a 28-year-old female patient with an unicentric Castleman disease. Computed tomography and magnetic resonance imaging revealed a well-circumscribed large mass in the left neck, characterized by intense homogenous enhancement and suspected for a malignant disease. The patient underwent an excisional biopsy for definitive diagnosis of unicentric Castleman disease and ruled out malignant conditions.

References

Simpson D. Epidemiology of Castleman disease. Hematol Oncol Clin North Am.2018;32(1):1-10.

Dispenzieri A, Fajgenbaum DC. Overview of Castleman disease. Blood. 2020 Apr 16;135(16):1353-1364.

Oksenhendler E, Boulanger E, Galicier L, et al. High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease. Blood. 2002;99(7):2331-2336.

Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer. 1956;9(4):822-830.

Mitsos S, Stamatopoulos A, Patrini D, George RS, Lawrence DR, Panagiotopoulos N. The role of surgical resection in Unicentric Castleman's disease: a systematic review. Adv Respir Med. 2018;86(1):36-43.

Madan R, Chen JH, Trotman-Dickenson B, Jacobson F, Hunsaker A. The spectrum of Castleman's disease: mimics, radiologic pathologic correlation and role of imaging in patient management. Eur J Radiol. 2012 Jan;81(1):123-31.

Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer. 1972;29(3):670-683.

Soumerai JD, Sohani AR, Abramson JS. Diagnosis and management of Castleman disease. Cancer Control. 2014 Oct;21(4):266-78.

Chronowski GM, Ha CS, Wilder RB, Cabanillas F, Manning J, Cox JD. Treatment of unicentric and multicentric Castleman disease and the role of radiotherapy. Cancer 2001;92:670-676.

Talat N, Belgaumkar AP, Schulte KM. Surgery in Castleman’s disease: a systematic review of 404 published cases. Ann Surg. 2012;255(4):677-684.

Downloads

Published

08-03-2023

Issue

Section

Case Reports: Oncology and Hematology

How to Cite

1.
Paparella MT, Popolizio T, Grasso D, Serricchio EA, Guglielmi G. Castleman disease: a rare case in a young woman. Acta Biomed [Internet]. 2023 Mar. 8 [cited 2024 Jul. 18];94(S1):e2023058. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/13795