Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning
Keywords:
Adolescents, acetaminophen, acute poisoning, N-acetylcysteine, suicide attemptAbstract
During the outbreak of COVID19 measures taken to contain the spread of the virus have influenced the mental well-being of adults and adolescents. Acetaminophen overdose is the major cause of drug intoxication among children and adolescents. We reported a case of a 15-year- old girl referred to our Emergency Department 3 hours after ingestion of 10 g of paracetamol for suicidal purposes. She promptly started the administration of intravenous N-acetylcysteine (NAC) and the patient was discharged after 5 days of hospitalization in good clinical condition and with neuropsychiatric follow-up. Our case shows that the timing of the intravenous NAC administration is considered the most important factor in the prevention of acetaminophen-induced hepatic failure, despite high serum levels after acetaminophen ingestion.
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Copyright (c) 2023 Serena Ferretti, Antonietta Curatola, Antonio Chiaretti, Benedetta Graglia, Antonio Gatto, Lavinia Capossela, Valeria Pansini
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