Use of remdesivir in children with COVID-19 infection: a quick narrative review

Andrea La Tessa; Marco Antonio Motisi; Gian Luigi Marseglia; Fabio Cardinale; Amelia Licari; Sara Manti; Mariangela Tosca; Michele Miraglia Del Giudice; Maria De Filippo; Luisa Galli; Elena  Chiappini

doi:10.23750/abm.v92iS7.12396

Use of remdesivir in children with COVID-19 infection: a quick narrative review

Authors

Andrea La Tessa Department of Pediatric Infectious Disease, Anna Meyer Children’s Hospital, Firenze, Italy
Marco Antonio Motisi Department of Pediatric Infectious Disease, Anna Meyer Children’s Hospital, Firenze, Italy
Gian Luigi Marseglia Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy
Fabio Cardinale Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy
Amelia Licari Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy
Sara Manti Department of Clinical and Experimental Medicine, Pediatric Respiratory Unit, San Marco Hospital, University of Catania, Catania, Italy
Mariangela Tosca Allergy Centre, IRCCS G. Gaslini Pediatric Hospital, Genova, Italy
Michele Miraglia Del Giudice Department of Woman, Child and of General and Specialized Surgery, University of Campania ‘Luigi Vanvitelli’, Naples, Italy
Maria De Filippo Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy
Luisa Galli Department of Pediatric Infectious Disease, Anna Meyer Children’s Hospital, Firenze, Italy
Elena Chiappini Division of Paediatric Infectious Disease, Anna Meyer Children's University Hospital, Department of Health Sciences, University of Florence, Florence, Italy.

DOI: https://doi.org/10.23750/abm.v92iS7.12396

Keywords:

COVID-19, Children, SARS-CoV-2, Antiviral drugs

Abstract

SARS-CoV-2 infection has a severe course in a small percentage of children. Remdesivir has shown promising results in reducing hospitalisation time in adults, but data on mortality rate are conflicting and few studies are available on its use use in antivirals in children. We performed a quick narrative review of the available literature data regarding the usage of remdesivir in children and neonates. In children, remdesivir showed good safety profile, however bradicardia events have been reported in children. Remdesivir is currently recommended by several guidelines in some subgroups of children with severe COVID-19, and should also be considered in critically ill patients, always in the context of the overall clinical picture and drug availability.

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