Antimicrobial properties of a new polymeric material based on poly(2-hydroxyethyl methacrylate)

Roman Chornopyshchuk; Vasyl Nagaichuk; Igor  Gerashchenko; Halyna Nazarchuk; Olena Kukolevska; Nataliia Chornopyshchuk; Svetlana Sidorenko

doi:10.23750/abm.v93i1.12243

Antimicrobial properties of a new polymeric material based on poly(2-hydroxyethyl methacrylate)

Authors

Roman Chornopyshchuk PhD, MD https://orcid.org/0000-0001-5422-7495
Vasyl Nagaichuk Dr. habil, Professor https://orcid.org/0000-0001-6345-4921
Igor Gerashchenko Dr. habil, Professor https://orcid.org/0000-0001-8796-9137
Halyna Nazarchuk PhD, MD https://orcid.org/0000-0003-3902-1741
Olena Kukolevska PhD https://orcid.org/0000-0002-1064-4083
Nataliia Chornopyshchuk PhD, MD https://orcid.org/0000-0003-3742-8230
Svetlana Sidorenko PhD, MD https://orcid.org/0000-0002-0971-2819

DOI: https://doi.org/10.23750/abm.v93i1.12243

Keywords:

Wound Infection, Local Antimicrobial Agents, Wound Dressings, Poly(2-hydroxyethylmethacrylate), Controlled Release.

Abstract

Background and aim. Оne of the promising areas is the development of synthetic wound dressings with programmed release of active substances that can affect various elements in the pathogenesis of the wound process. The aim was to study the antimicrobial properties of a new polymeric material based on poly(2-hydroxyethyl methacrylate).

Methods: 2-hydroxyethyl methacrylate, dimethacrylate triethylene glycol as crosslinking agent, polymerization initiator of azobisizobutyronitrile along with a porogen and one of the antimicrobial agents, including decamethoxin, chlorhexidine bigluconate, silver nitrate, octenidine, furacilin, metronidazole, dioxidine, and gentamicin were used to synthesize a new material with antimicrobial activity. For comparison, polymer samples synthesized without adding antimicrobials were used, as well as known dressing materials: carbon material, porcine skin, which were immersed into 0.02% decamethoxin solution before use, as well as silver-containing dressing, hydrogel dressings, including those filled with silver. Determination of antibacterial properties was performed by diffusionmethod.

Results. Low antimicrobial activity of the studied existing wound dressings, which are widely used in medical practice, even under conditions of their saturation with antiseptic substances, has been established. Samples of the suggested polymeric material with the addition of antimicrobial substances showed the ability to inhibit the growth of the test strains of microorganisms at a sufficient level, especially with such fillers as decamethoxin, gentamicin, dioxidine. When metronidazole was added to the polymeric material, a reliable antimicrobial effect on the anaerobic microorganisms was established.

Conclusions.Modification of the polymeric material of poly(2-hydroxyethyl methacrylate) by adding antimicrobial substances allows to ensure its high antimicrobial properties against different microorganisms.

Author Biographies

Roman Chornopyshchuk, PhD, MD

Department of General Surgery, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Vasyl Nagaichuk, Dr. habil, Professor

Department of General Surgery, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Igor Gerashchenko, Dr. habil, Professor

Department of Biomedical Problems Surface № 6, Chuiko Institute of Surface Chemistry, NAS of Ukraine, Kyiv, Ukraine

Halyna Nazarchuk, PhD, MD

Department of Ophthalmology, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Olena Kukolevska, PhD

Department of Pharmaceutical Chemistry, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Nataliia Chornopyshchuk, PhD, MD

Department of Pediatric №1, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Svetlana Sidorenko, PhD, MD

Department of Neurological, Musculoskeletal and Oncologic Rehabilitation, Clinic Bad Ragaz, Bad Ragaz, Switzerland

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