Implications of Interleukin-6 (IL-6)-blockade for severe COVID-19 infection in patients with Multiple Myeloma

NICOLA SGHERZA; PAOLA CURCI; VANDA STRAFELLA; RITA RIZZI; PELLEGRINO MUSTO

doi:10.23750/abm.v92i2.11395

Implications of Interleukin-6 (IL-6)-blockade for severe COVID-19 infection in patients with Multiple Myeloma

Authors

NICOLA SGHERZA a:1:{s:5:"en_US";s:147:"Hematology and Bone Marrow Transplantation Unit - AOUC Policlinico, Department of Emergency and Organ Transplantation, "Aldo Moro" University, Bari";}
PAOLA CURCI Hematology and Bone Marrow Transplantation Unit - AOUC Policlinico, Department of Emergency and Organ Transplantation, "Aldo Moro" University, 70124, Bari, Italy
VANDA STRAFELLA Hematology and Bone Marrow Transplantation Unit - AOUC Policlinico, Department of Emergency and Organ Transplantation, "Aldo Moro" University, 70124, Bari, Italy
RITA RIZZI Hematology and Bone Marrow Transplantation Unit - AOUC Policlinico, Department of Emergency and Organ Transplantation, "Aldo Moro" University, 70124, Bari, Italy
PELLEGRINO MUSTO Hematology and Bone Marrow Transplantation Unit - AOUC Policlinico, Department of Emergency and Organ Transplantation, "Aldo Moro" University, 70124, Bari, Italy

DOI: https://doi.org/10.23750/abm.v92i2.11395

Keywords:

multiple myeloma, COVID-19, IL-6, tocilizumab, siltuximab, sarilumab

References

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2. Crisafulli S, Isgrò V, La Corte L, Atzeni F, Trifirò G. Potential Role of Anti-interleukin (IL)-6 Drugs in the Treatment of COVID-19: Rationale, Clinical Evidence and Risks. BioDrugs. 2020 Aug;34(4):415-422. doi: 10.1007/s40259-020-00430-1. PMID: 32557214; PMCID: PMC7299248

3. Atal S, Fatima Z. IL-6 Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy? Pharmaceut Med. 2020 Aug;34(4):223-231. doi: 10.1007/s40290-020-00342-z. PMID: 32535732; PMCID: PMC7292936.
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5. Hirata T, Shimazaki C, Sumikuma T, Ashihara E, Goto H, Inaba T, Koishihara Y, Nakagawa M. Humanized anti-interleukin-6 receptor monoclonal antibody induced apoptosis of fresh and cloned human myeloma cells in vitro. Leuk Res. 2003 Apr;27(4):343-9. doi: 10.1016/s0145-2126(02)00179-0. PMID: 12531226.

6. Matsuyama Y, Nagashima T, Honne K, Kamata Y, Iwamoto M, Okazaki H, Sato K, Ozawa K, Minota S. Successful treatment of a patient with rheumatoid arthritis and IgA-κ multiple myeloma with tocilizumab. Intern Med. 2011;50(6):639-42. doi: 10.2169/internalmedicine.50.4636. Epub 2011 Mar 15. PMID: 21422694.

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Published

12-05-2021

Issue

Vol. 92 No. 2 (2021): Vol. 92 No. 2 (2021): COVID-19 Update

Section

CORRESPONDENCE - SPECIAL COVID19

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How to Cite

SGHERZA N, CURCI P, STRAFELLA V, RIZZI R, MUSTO P. Implications of Interleukin-6 (IL-6)-blockade for severe COVID-19 infection in patients with Multiple Myeloma. Acta Biomed [Internet]. 2021 May 12 [cited 2024 Aug. 17];92(2):e2021205. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/11395

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