Effect of chloroquine on some clinical and biochemical parameters in non-response chronic hepatitis C virus infection patients: pilot clinical trial

Effect of chloroquine on some clinical and biochemical parameters in non-response chronic hepatitis C virus infection patients: pilot clinical trial

Authors

  • Payam Peymani Health policy Research Center,Shiraz University of Medical Sciences, Shiraz, Iran.
  • Saied Ghavami Health policy Research Center,Shiraz University of Medical Sciences, Shiraz, Iran and Department of Human Anatomy and Cell Science, Children Hospital Research Institute of Manitoba, Biology of Breathing Theme, University of Manitoba, Winnipeg, Manitoba, Canada
  • Behzad Yeganeh Program in Physiology & Experimental Medicine, Hospital for Sick Children Research Institute and University of Toronto, Toronto, Canada
  • Reza Tabrizi Health policy Research Center,Shiraz University of Medical Sciences, Shiraz, Iran.
  • Siamak Sabour Safety Promotion and Injury Prevention Research Center and Department of Clinical Epidemiology, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
  • Bita Geramizadeh Department of Pathology and Organ Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mohammad Reza Fattahi Department of Internal Medicine and Gastroenterohepatology Research Center, School of Medicine, Shiraz University of Medical sciences, Shiraz,
  • Seyed Mehdi Ahmadi Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Kamran B. Lankarani Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Keywords:

Anthropometric parameters, thyroid function, biochemical parameter, chronic hepatitis C virus, non-response patients, chloroquine,

Abstract

Background: Hepatitis C virus infection frequently leads to chronic hepatitis C which may progress to cirrhosis and can be ended to hepatocellular carcinoma. This study aimed to investigate the effect of Anthropometric Parameters, Vit D3, Thyroid Function, Ferritin and Biochemistry Parameters in patients chronically infected with HCV with non-response criteria which was treated by chloroquine.

Methods: This study was the continuation of our previous investigation with a triple-blind method in a randomized controlled pilot study. After understanding the study procedures, patients signed an informed consent form and were randomized into the treatment (chloroquine 150 mg once daily, for 8 weeks) and control (placebo once daily, for 8 weeks) groups. The inclusion criteria were male, between 18 and 60 years of age, confirmed chronic hepatitis C with non-response criteria, and Genotype 1.  Data were analyzed with an intention to treat perspective at the end follow up (12 weeks) considering to variables such as anthropometric parameters, Vit D3, thyroid function, ferritin and biochemistry parameters evaluated.

Results: Although there were decreases in total weight (P-value=0.4), mid-arm circumference (P-value=0.05), and body mass index (P-value=0.04) there were increases in total body fat (P-value=0.8) and triceps skin fold thickness  (P-value=0.7) in the intervention group compared to the control group. Also, a reduction of AST (P-value=0.30), ALT (P-value=0.10), cholesterol (P-value=0.005), triglyceride (P-value=0.40) and ferritin (P-value=0.030) levels was seen in the intervention group during the follow up period. Our results also showed that serum TSH levels (P-value=0.5) were slightly higher in the chloroquine group than in the placebo group, though the trend was reversed for T3 (P-value=0.05) and T4 (P-value=0.04) levels. however, median of T3 and T4 were similar in both groups. A significant increase in vitamin D levels from 15 to 34 ng/ml was observed in the chloroquine group (P-value=0.04).

Conclusions: The results suggest that chloroquine therapy may be very useful for HCV treatment in patients with non-response criteria, and helps to normalize some anthropometric parameters, biochemical, ferritin, and vitamin D status.

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Published

06-05-2016

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Section

ORIGINAL ARTICLES

How to Cite

1.
Effect of chloroquine on some clinical and biochemical parameters in non-response chronic hepatitis C virus infection patients: pilot clinical trial. Acta Biomed [Internet]. 2016 May 6 [cited 2024 Jun. 24];87(1):46-53. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/4987