The concept of multiple hormonal dysregulation

The concept of multiple hormonal dysregulation

Authors

  • Marcello Maggio Department of Internal and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy; Geriatric-Rehabilitation Department, University Hospital of Parma, Parma Italy
  • Chiara Cattabiani Geriatric-Rehabilitation Department, University Hospital of Parma, Parma Italy
  • Fulvio Laurentani Geriatric-Rehabilitation Department, University Hospital of Parma, Parma Italy
  • Luigi Ferrucci Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA
  • Michele Luci Geriatric-Rehabilitation Department, University Hospital of Parma, Parma Italy
  • Giorgio Valenti Department of Internal and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
  • Gian Paolo Ceda Department of Internal and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy; Geriatric-Rehabilitation Department, University Hospital of Parma, Parma Italy

Keywords:

Anabolic hormones, frailty, mortality

Abstract

Aging process is accompanied by hormonal changes characterized by an imbalance between catabolic hormones that remain stable and anabolic hormones (testosterone, insulin like growth factor-1 (IGF-1) and dehydroepiandrosterone sulphate (DHEAS), that decrease with age. Despite the multiple hormonal dysregulation occurring with age, the prevalent line of research in the last decades has tried to explain many age-related phenomena as consequence of one single hormonal derangement with disappointing results. In this review we will list the relationship between hormonal anabolic deficiency and frailty and mortality in older population, providing evidence to the notion that multiple hormonal dysregulation rather than change in single anabolic hormone is a powerful marker of poor health status and mortality.

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Published

01-03-2010

How to Cite

1.
The concept of multiple hormonal dysregulation. Acta Biomed [Internet]. 2010 Mar. 1 [cited 2024 May 30];81(1Suppl):19-2. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/4631

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