A role of the TRAIL-TRAIL receptor system in the pathogenesis of diabetes

A role of the TRAIL-TRAIL receptor system in the pathogenesis of diabetes

Authors

  • Mauro Vaccarezza Department of Health and Motor Sciences, University of Cassino, Cassino (FR), Italy
  • Giorgio Delbello Department of Human Normal Morphology, University of Trieste, Trieste, Italy
  • Giorgio Zauli Department of Human Normal Morphology, University of Trieste, Trieste, Italy

Keywords:

TRAIL, diabetes, HUVEC, streptozotocin, NO

Abstract

The TNF-a super-family of cytokines comprises structurally related proteins that play pivotal roles in regulating cell death, immune response and inflammation. A new member of the family namely Tumor necrosis factor alpha-Related Apoptosis-Inducing Ligand (TRAIL) is involved not only in apoptosis and immune regulation, but also it has a provocative role in vascular biology as reported recently. In this report we provide evidence that this new function of TRAIL may have a significance in the pathogenesis of diabetes and in particular in the vascular alterations that occur late during the natural history of the illness. Noteworthy, depending on the type of diabetes and on the disease stage,TRAIL can have a dual role, either as immune modulator as well as a regulatory molecule of the vascular wall fitness.

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Published

01-03-2007

Issue

Vol. 78 No. 1Suppl (2007): New frontiers and modelling in neural, endocrine and immune communication

Section

ORIGINAL ARTICLES

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Vaccarezza M, Delbello G, Zauli G. A role of the TRAIL-TRAIL receptor system in the pathogenesis of diabetes. Acta Biomed [Internet]. 2007 Mar. 1 [cited 2024 Jul. 27];78(1Suppl):262-7. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/4627