Dancing eye syndrome as first symptom of neuroblastoma

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Cristina Venturelli
Azzurra Guerra
Paolo Paolucci
Lorenzo Iughetti


Opsoclonus-Myoclonus Syndrome, dancing eye syndrome, neuroblastoma, paraneoplastic neurologic disorder


Background: “Dancing eye syndrome”, also called Kinsbourne syndrome or Opsoclonus-Myoclonus-Ataxia Syndrome (OMS) is a rare neurological disorder that in children is frequently associated to occult, low-grade neuroblastoma (NB) (>50% of the cases). OMS may also be triggered by infections and it is often associated to developmental impairment and disability.

Case presentation: We discuss the case of a 16 months old female with acutely onset of OMS associated to occult stage III NB.

Conclusions: OMS represents a diagnostic challenge for pediatric clinicians. The suspect of OMS imposes the search for an occult NB in order to promptly treat a life-threatening event like tumor and to prevent the neurological sequels linked to OMS.


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