Certolizumab: efficacy and safety profile of a novel pegylatedTNF-alpha blocking agent

Certolizumab: efficacy and safety profile of a novel pegylatedTNF-alpha blocking agent

Authors

  • E. Lubrano
  • A. Spadaro

Keywords:

Certolizumab, anti TNF-a, drugs, rheumatoid arthritis

Abstract

The treatment of Rheumatoid Arthritis (RA) has changed since the introduction of biological agents. In particular, the anti Tumor Necrosis Factor (TNF)-α molecules have been the first group of drugs showing a good efficacy and safety profile. Among these, a new anti TNF-α antibody has been recently indicated for the treatment of RA: certolizumab pegol (CZP). In the main clinical trials this new pegylated anti TNF-α has shown to be efficacious on clinical, functional and prevention of structural damage in patients with active RA and with inadequate response to traditional disease modifying drugs, including methotrexate. Moreover CZP showed to be well tolerated and most adverse events occurred were mild or moderate. Therefore, results obtained showed that this new molecule can play a role in the treatment of RA.

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Published

01-09-2011

Issue

Section

ORIGINAL ARTICLES

How to Cite

1.
Certolizumab: efficacy and safety profile of a novel pegylatedTNF-alpha blocking agent. Acta Biomed [Internet]. 2011 Sep. 1 [cited 2024 May 30];82(1):26-34. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/1362