A case of disseminated nontuberculous mycobacteriosis and cerebellar toxoplasmosis with autoantibody to interferon-γ

A case of disseminated nontuberculous mycobacteriosis and cerebellar toxoplasmosis with autoantibody to interferon-γ

Authors

  • Etsuro Yamaguchi Division of Respiratory Medicine and Allergology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • H. Tanaka Division of Respiratory Medicine and Allergology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • Takaaki Fukuoka Division of Neurology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • Y. Ohbayashi Department of Obstetrics and Gynecology, Aichi Medical University School of Medicine
  • M. Sato Department of Physiology , Aichi Medical University School of Medicine
  • T. Yokoi Department of Diagnostic Pathology, Aichi Medical University Hospital

Keywords:

NTM, toxoplasmosis, measles, herpes zoster, herpes simplex, autoantibody, interferon-γ

Abstract

Autoantibody against interferon-γ has recently been associated with a variety of opportunisticinfections, particularly among Asians. We report the case of a 64-year-old Japanese woman who suffered from concomitant or sequential infections of the skin, lungs, bronchi, uterus, andbladder with nontuberculous mycobacteriosis, cerebellar toxoplasmosis, measles,herpes zoster, and vulvar herpes. Blood mononuclear cells from the patient displayed intact cytokine production in response to various stimuli and interferon-γ. High-titer anti-interferon-γ autoantibodies were detected in her serum. The atypical pathology hampered early diagnosis, but indeterminate results of an interferon-γ release assay could offer a simple clue suggesting the presence of autoantibody.

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Published

17-12-2013

Issue

Vol. 30 No. 4 (2013)

Section

Case Reports

License

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How to Cite

1.
Yamaguchi E, Tanaka H, Fukuoka T, Ohbayashi Y, Sato M, Yokoi T. A case of disseminated nontuberculous mycobacteriosis and cerebellar toxoplasmosis with autoantibody to interferon-γ. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2013 Dec. 17 [cited 2025 May 20];30(4):312-6. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/2848