Assessment of a Systematic Screening of Occupational Exposures in Malignant Hemopathies in the Rhone-Alpes Area: Prolymphome Study
Main Article Content
Keywords
malignant hemopathies, self-administered questionnaires, occupational exposures, occupational disease, social vulnerability
Abstract
Background: Several studies have highlighted the role of environmental exposures in malignant hemopathies etiology. Some patients with malignant hemopathies can be compensated as occupational diseases. The Prolymphome research aimed to assess a systematic screening of occupational exposures in patients with lymphoma or myeloma treated in three hospitals in the Rhône-Alpes region. Methods: Patients received a self-administered questionnaire to fill in at home to collect their job history and potential occupational exposures to carcinogens. A physician assessed the questionnaire to determine if a dedicated consultation was required and the possibility of claiming compensation. Patients were systematically assisted by a social worker for administrative procedures. Results: In 12 months, 754 patients were enrolled in the study, and 361 (48%) returned the questionnaire. A specialized consultation was proposed for 123 patients, and 98 patients attended the consultation. Overall, a compensation claim was proposed to 18 patients: 11 have been occupationally exposed to pesticides and seven to trichloroethylene. Conclusions: Our results confirmed the feasibility of the systematic screening procedure. Barriers were observed at every step of the process, and it underlined that patients are rarely nformed about occupational exposures. As the prevalence of occupational exposures in malignant hemopathies remains scarce, a systematic targeted screening could be relevant in this population.
References
1. Defossez G, Guyader‑Peyrou S, Uhry Z, et al. Estimations nationales de l’incidence et de la mortalité par cancer en France métropolitaine entre 1990 et 2018. Santé Publique France, 2019, 372 pp.
2. An Z-Y, Fu H, He Y, et al. Projected Global Trends in Hematological Malignancies: Incidence, Mortality, and Disability-Adjusted Life Years from 2020 to 2030. Blood. 2023;142:3810‑3810.
3. Sharma R. Global, regional, national burden of breast cancer in 185 countries: evidence from GLO-BOCAN 2018. Breast Cancer Res Treat. 2021;187:557‑67.
4. Park W-J, Park J, Cho S, Shin MG. Twenty-year incidence trend of hematologic malignancies in the Re-public of Korea: 1999-2018. Blood Res. 2021;56:301‑14.
5. Sant M, Allemani C, Tereanu C, et al. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood. 2010;116:3724‑34.
6. Zhang N, Wu J, Wang Q, et al. Global burden of hematologic malignancies and evolution patterns over the past 30 years. Blood Cancer J. 2023;13:82.
7. Alexander DD, Mink PJ, Adami H-O, et al. The non-Hodgkin lymphomas: A review of the epidemiologic literature. Int J Cancer. 2007;120:1‑39.
8. Descatha A, Jenabian A, Conso F, Ameille J. Occupational Exposures and Haematological Malignancies: Overview on Human Recent Data. Cancer Causes Control. 2005;16:939‑53.
9. Francisco LFV, Da Silva RN, Oliveira MA , et al. Occupational Exposures and Risks of Non-Hodgkin Lymphoma: A Meta-Analysis. Cancers. 2023;15:2600.
10. Pasqualetti P, Casale R, Colantonio D, Collacciani A. Occupational risk for hematological malignancies. American J Hematol. 1991;38:147‑9.
11. Hours M, Fevotte J, Ayzac L, et al. [Occupational exposure and malignant hemopathies: a case-control study in Lyon (France)]. Rev Epidemiol Sante Publique. 1995;43:231‑41.
12. Moura LTRD, Bedor CNG, Lopez RVM, et al. Exposição ocupacional a agrotóxicos organofosforados e neoplasias hematológicas: uma revisão sistemática. Rev Bras Epidemiol. 2020;23:e200022.
13. Batista JL, Birmann BM, Epstein MM. Epidemiology of Hematologic Malignancies. In: Loda M, Mucci LA, Mittelstadt ML, Van Hemelrijck M, Cotter MB, éditeurs. Pathology and Epidemiology of Cancer [Internet]. Cham: Springer International Publishing; 2017 [cité 2 août 2023]. p. 543‑69. Disponible sur: http://link.springer.com/10.1007/978-3-319-35153-7_29
14. Schinasi L, Leon M. Non-Hodgkin Lymphoma and Occupational Exposure to Agricultural Pesticide Chemical Groups and Active Ingredients: A Systematic Review and Meta-Analysis. IJERPH. 2014;11:4449‑527.
15. IARC/CIRC (International Agency for Research on Cancer). Les cancers attribuables au mode de vie et à l’environnement en France métropolitaine [Internet]. Lyon, France: International Agency for Research on Cancer/Centre International de Recherche sur le Cancer, Section Surveillance du Cancer; 2018 p. 271. Disponible sur: https://gco.iarc.fr/includes/PAF/PAF_FR_report.pdf
16. Leon ME, Schinasi LH, Lebailly P, et al. Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH con-sortium. Int J Epidemiol. 2019;48:1519‑35.
17. Kachuri L, Beane Freeman LE, Spinelli JJ, et al. Insecticide use and risk of non‐Hodgkin lymphoma subtypes: A subset meta‐analysis of the North American Pooled Project. Int J Cancer. 2020; 147: 3370‑83.
18. De Roos AJ, Schinasi LH, Miligi L, et al. Occupational insecticide exposure and risk of nOn‐Hodgkin lymphoma: A pooled case‐control study from the InterLymph Consortium. Int J Cancer. 2021;149:1768‑86.
19. ‘T Mannetje A, De Roos AJ, Boffetta P, et al. Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium. Environ Health Perspect. 2016;124:396‑405.
20. International Agency for Research on Cancer. List of classifications by cancer sites with sufficient or limited evidence in humans, IARC Monographs Volumes 1–134 [Internet]. 2023. Disponible sur: https://monographs.iarc.who.int/wp-content/uploads/2019/07/Classifications_by_cancer_site.pdf
21. INRS. Tableaux des maladies professionnelles [Internet]. 2024. Disponible sur: https://www.inrs.fr/publications/bdd/mp.html
22. Bassig BA, Friesen MC, Vermeulen R, et al. Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women’s Health Study. Environ Health Per-spect. 2015;123:971‑7.
23. Charbotel B, Fervers B, Droz JP. Occupational exposures in rare cancers: A critical review of the liter-ature. Critical Reviews in Oncology/Hematology. 2014;90:99‑134.
24. Orsi L, Delabre L, Monnereau A, et al. Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study. Occup Environ Med. 2009;66:291‑8.
25. Khuder S, Mutgi A, Schaub E, Tano B. Meta-analysis of Hodgkin’s disease among farmers. Scand J Work Environ Health. 1999;25:436‑41.
26. McCunney RJ. Hodgkin’s Disease, Work, and the Environment: A Review. J Occup Environ Med. 1999;41:36‑46.
27. Curti S, Sauni R, Spreeuwers D, et al. Interventions to increase the reporting of occupational diseases by physicians. Cochrane Work Group, éditeur. Cochrane Database of Systematic Reviews. 2015; https://doi.wiley.com/10.1002/14651858.CD010305.pub2
28. Sarfo M-C, Bertels L, Frings-Dresen MHW, et al. The role of general practitioners in the work guidance of cancer patients: views of general practitioners and occupational physicians. J Cancer Surviv. 2022 https://link.springer.com/10.1007/s11764-022-01211-1
29. Britel M, Pérol O, Blois Da Conceiçao S, et al. [Motivations and obstacles to occupational disease claims in lung cancer patients: an exploratory psychosocial study]. Sante Publique. 2017;29:569‑78.
30. Eurogip. Reporting of occupational diseases: issues and good practices in five European countries. 2015; Disponible sur: http:// www.eurogip.fr/images/publications/2015/Report_DeclarationMP_ EUROGIP_102EN.pdf
31. Cellier C, Charbotel B, Carretier J, et al. [Identification of occupational exposures among patients with lung cancer]. Bull Cancer. 2013;100:661‑70.
32. Varin M, Charbotel B, Pérol O, et al. [Assessment of a self-administered questionnaire identifying oc-cupational exposures among lung cancer patients]. Bull Cancer. 2017;104:559‑64.
33. Pérol O, Charbotel B, Perrier L, et al. Systematic Screening for Occupational Exposures in Lung Cancer Patients: A Prospective French Cohort. Int J Environ Res Public Health. 2018;15(1):65. Published 2018 Jan 4. doi:10.3390/ijerph15010065
34. Sass C, Sass C, Moulin Jj, et al. Le score Épices : un score individuel de précarité. Construction du score et mesure des relations avec des données de santé, dans une population de 197 389 personnes. Bull. Épidémiol. Hebd. , 2006, n°. 14, p. 93-6
35. Labbe E, Blanquet M, Gerbaud L, et al. A new reliable index to measure individual deprivation: the EPICES score. Eur J Public Health. 2015;25:604‑9.
36. Bonneterre V, Faisandier L, Bicout D, et al. Programmed health surveillance and detection of emerging diseases in occupational health: contribution of the French national occupational disease surveillance and prevention network (RNV3P). Occup Environ Med. 2010;67:178‑86.
37. Marant Micallef C, Charvat H, Houot M-T, et al. Estimated number of cancers attributable to occupa-tional exposures in France in 2017: an update using a new method for improved estimates. J Expo Sci Environ Epidemiol [Internet]. 2021 [cité 9 juin 2022]; Disponible sur: http://www.nature.com/articles/s41370-021-00353-1
38. Matrat M, Gain M, Haioun C, et al. Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study. IJERPH. 2021;18:4008.
39. Légifrance. Décret n° 2020-1463 du 27 novembre 2020 relatif à l’indemnisation des victimes de pesti-cides. 2020. Disponible sur: https://www.legifrance.gouv.fr/jorf/id/JORFTEXT000042576881
40. Pérol O, Lepage N, Noelle H, et al. A Multicenter Study to Assess a Systematic Screening of Occupa-tional Exposures in Lung Cancer Patients. IJERPH. 2023;20:5068.
2. An Z-Y, Fu H, He Y, et al. Projected Global Trends in Hematological Malignancies: Incidence, Mortality, and Disability-Adjusted Life Years from 2020 to 2030. Blood. 2023;142:3810‑3810.
3. Sharma R. Global, regional, national burden of breast cancer in 185 countries: evidence from GLO-BOCAN 2018. Breast Cancer Res Treat. 2021;187:557‑67.
4. Park W-J, Park J, Cho S, Shin MG. Twenty-year incidence trend of hematologic malignancies in the Re-public of Korea: 1999-2018. Blood Res. 2021;56:301‑14.
5. Sant M, Allemani C, Tereanu C, et al. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood. 2010;116:3724‑34.
6. Zhang N, Wu J, Wang Q, et al. Global burden of hematologic malignancies and evolution patterns over the past 30 years. Blood Cancer J. 2023;13:82.
7. Alexander DD, Mink PJ, Adami H-O, et al. The non-Hodgkin lymphomas: A review of the epidemiologic literature. Int J Cancer. 2007;120:1‑39.
8. Descatha A, Jenabian A, Conso F, Ameille J. Occupational Exposures and Haematological Malignancies: Overview on Human Recent Data. Cancer Causes Control. 2005;16:939‑53.
9. Francisco LFV, Da Silva RN, Oliveira MA , et al. Occupational Exposures and Risks of Non-Hodgkin Lymphoma: A Meta-Analysis. Cancers. 2023;15:2600.
10. Pasqualetti P, Casale R, Colantonio D, Collacciani A. Occupational risk for hematological malignancies. American J Hematol. 1991;38:147‑9.
11. Hours M, Fevotte J, Ayzac L, et al. [Occupational exposure and malignant hemopathies: a case-control study in Lyon (France)]. Rev Epidemiol Sante Publique. 1995;43:231‑41.
12. Moura LTRD, Bedor CNG, Lopez RVM, et al. Exposição ocupacional a agrotóxicos organofosforados e neoplasias hematológicas: uma revisão sistemática. Rev Bras Epidemiol. 2020;23:e200022.
13. Batista JL, Birmann BM, Epstein MM. Epidemiology of Hematologic Malignancies. In: Loda M, Mucci LA, Mittelstadt ML, Van Hemelrijck M, Cotter MB, éditeurs. Pathology and Epidemiology of Cancer [Internet]. Cham: Springer International Publishing; 2017 [cité 2 août 2023]. p. 543‑69. Disponible sur: http://link.springer.com/10.1007/978-3-319-35153-7_29
14. Schinasi L, Leon M. Non-Hodgkin Lymphoma and Occupational Exposure to Agricultural Pesticide Chemical Groups and Active Ingredients: A Systematic Review and Meta-Analysis. IJERPH. 2014;11:4449‑527.
15. IARC/CIRC (International Agency for Research on Cancer). Les cancers attribuables au mode de vie et à l’environnement en France métropolitaine [Internet]. Lyon, France: International Agency for Research on Cancer/Centre International de Recherche sur le Cancer, Section Surveillance du Cancer; 2018 p. 271. Disponible sur: https://gco.iarc.fr/includes/PAF/PAF_FR_report.pdf
16. Leon ME, Schinasi LH, Lebailly P, et al. Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH con-sortium. Int J Epidemiol. 2019;48:1519‑35.
17. Kachuri L, Beane Freeman LE, Spinelli JJ, et al. Insecticide use and risk of non‐Hodgkin lymphoma subtypes: A subset meta‐analysis of the North American Pooled Project. Int J Cancer. 2020; 147: 3370‑83.
18. De Roos AJ, Schinasi LH, Miligi L, et al. Occupational insecticide exposure and risk of nOn‐Hodgkin lymphoma: A pooled case‐control study from the InterLymph Consortium. Int J Cancer. 2021;149:1768‑86.
19. ‘T Mannetje A, De Roos AJ, Boffetta P, et al. Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium. Environ Health Perspect. 2016;124:396‑405.
20. International Agency for Research on Cancer. List of classifications by cancer sites with sufficient or limited evidence in humans, IARC Monographs Volumes 1–134 [Internet]. 2023. Disponible sur: https://monographs.iarc.who.int/wp-content/uploads/2019/07/Classifications_by_cancer_site.pdf
21. INRS. Tableaux des maladies professionnelles [Internet]. 2024. Disponible sur: https://www.inrs.fr/publications/bdd/mp.html
22. Bassig BA, Friesen MC, Vermeulen R, et al. Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women’s Health Study. Environ Health Per-spect. 2015;123:971‑7.
23. Charbotel B, Fervers B, Droz JP. Occupational exposures in rare cancers: A critical review of the liter-ature. Critical Reviews in Oncology/Hematology. 2014;90:99‑134.
24. Orsi L, Delabre L, Monnereau A, et al. Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study. Occup Environ Med. 2009;66:291‑8.
25. Khuder S, Mutgi A, Schaub E, Tano B. Meta-analysis of Hodgkin’s disease among farmers. Scand J Work Environ Health. 1999;25:436‑41.
26. McCunney RJ. Hodgkin’s Disease, Work, and the Environment: A Review. J Occup Environ Med. 1999;41:36‑46.
27. Curti S, Sauni R, Spreeuwers D, et al. Interventions to increase the reporting of occupational diseases by physicians. Cochrane Work Group, éditeur. Cochrane Database of Systematic Reviews. 2015; https://doi.wiley.com/10.1002/14651858.CD010305.pub2
28. Sarfo M-C, Bertels L, Frings-Dresen MHW, et al. The role of general practitioners in the work guidance of cancer patients: views of general practitioners and occupational physicians. J Cancer Surviv. 2022 https://link.springer.com/10.1007/s11764-022-01211-1
29. Britel M, Pérol O, Blois Da Conceiçao S, et al. [Motivations and obstacles to occupational disease claims in lung cancer patients: an exploratory psychosocial study]. Sante Publique. 2017;29:569‑78.
30. Eurogip. Reporting of occupational diseases: issues and good practices in five European countries. 2015; Disponible sur: http:// www.eurogip.fr/images/publications/2015/Report_DeclarationMP_ EUROGIP_102EN.pdf
31. Cellier C, Charbotel B, Carretier J, et al. [Identification of occupational exposures among patients with lung cancer]. Bull Cancer. 2013;100:661‑70.
32. Varin M, Charbotel B, Pérol O, et al. [Assessment of a self-administered questionnaire identifying oc-cupational exposures among lung cancer patients]. Bull Cancer. 2017;104:559‑64.
33. Pérol O, Charbotel B, Perrier L, et al. Systematic Screening for Occupational Exposures in Lung Cancer Patients: A Prospective French Cohort. Int J Environ Res Public Health. 2018;15(1):65. Published 2018 Jan 4. doi:10.3390/ijerph15010065
34. Sass C, Sass C, Moulin Jj, et al. Le score Épices : un score individuel de précarité. Construction du score et mesure des relations avec des données de santé, dans une population de 197 389 personnes. Bull. Épidémiol. Hebd. , 2006, n°. 14, p. 93-6
35. Labbe E, Blanquet M, Gerbaud L, et al. A new reliable index to measure individual deprivation: the EPICES score. Eur J Public Health. 2015;25:604‑9.
36. Bonneterre V, Faisandier L, Bicout D, et al. Programmed health surveillance and detection of emerging diseases in occupational health: contribution of the French national occupational disease surveillance and prevention network (RNV3P). Occup Environ Med. 2010;67:178‑86.
37. Marant Micallef C, Charvat H, Houot M-T, et al. Estimated number of cancers attributable to occupa-tional exposures in France in 2017: an update using a new method for improved estimates. J Expo Sci Environ Epidemiol [Internet]. 2021 [cité 9 juin 2022]; Disponible sur: http://www.nature.com/articles/s41370-021-00353-1
38. Matrat M, Gain M, Haioun C, et al. Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study. IJERPH. 2021;18:4008.
39. Légifrance. Décret n° 2020-1463 du 27 novembre 2020 relatif à l’indemnisation des victimes de pesti-cides. 2020. Disponible sur: https://www.legifrance.gouv.fr/jorf/id/JORFTEXT000042576881
40. Pérol O, Lepage N, Noelle H, et al. A Multicenter Study to Assess a Systematic Screening of Occupa-tional Exposures in Lung Cancer Patients. IJERPH. 2023;20:5068.
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Pérol O, Remion R, Charbotel B, Fervers B. Assessment of a Systematic Screening of Occupational Exposures in Malignant Hemopathies in the Rhone-Alpes Area: Prolymphome Study. Med Lav [Internet]. 2025 Apr. 17 [cited 2025 May 24];116(2):16270. Available from: https://mattioli1885journals.com/index.php/lamedicinadellavoro/article/view/16270
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How to Cite
1.
Pérol O, Remion R, Charbotel B, Fervers B. Assessment of a Systematic Screening of Occupational Exposures in Malignant Hemopathies in the Rhone-Alpes Area: Prolymphome Study. Med Lav [Internet]. 2025 Apr. 17 [cited 2025 May 24];116(2):16270. Available from: https://mattioli1885journals.com/index.php/lamedicinadellavoro/article/view/16270
