Occupational Risk Factors for Laryngeal Cancer in Tunisia: A Case Control Study Occupational Risk facors For Laryngeal cancer

Main Article Content

Asma Gaddour
Department of Occupational Medicine, Faculty of Medicine of Sousse, University of Sousse, Tunisia

Aicha Brahem
Department of Occupational Medicine, University Farhat Hached hospital, Sousse, Tunisia

Hiba Mosbah
Department of Occupational Medicine, Faculty of Medicine of Sousse, University of Sousse, Tunisia

Chaima Sridi
Department of Occupational Medicine, University Sahloul hospital, Sousse, Tunisia

Maroua Saidane
Department of Occupational Medicine, University Farhat Hached hospital, Sousse, Tunisia

Mouna Belakhdher
ENT Department, University Farhat Hached Hospital, Sousse, Tunisia

Asma Chouchene
Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia

Imen Kacem
Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia

Maher Maoua
Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia

Houda Kalboussi
Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia

Olfa El Maalel
Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia

Souheil Chatti
Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia

Wassim Kermani
ENT Department, University Farhat Hached Hospital, Sousse, Tunisia

Mrizek Najib
Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia

Keywords

Occupational, Laryngeal cancer, Epidemiology

Abstract


Background: Tobacco use and alcohol consumption are the primary risk factors for laryngeal cancer (LC). In most populations, occupational exposures are likely to play a minor role in laryngeal carcinogenesis. We aimed to investigate the association between occupational exposure and laryngeal cancer. Methods: It is a case-control study that included 140 cases diagnosed between January 2013 and December 2016 and 140 controls matched by sex, age, alcohol consumption, and tobacco consumption. Results: Significantly increased risks were found amongst workers of the building sector (OR=4.621; 95% CI [1.826-11.693]) and the mechanical industry sector (OR=5.074; 95% CI [1.425-18.072]). Significant association of laryngeal cancer with various carcinogens was observed such as asbestos (p=0.009; OR=3.68; 95% CI [1.29-10.46]), paint vapors (p=0.005; OR=3.35; 95% CI [1.37-8.16]), solvents (p=0.001; OR=3.29: 95% CI [1.61-6.68]) and cement dust (p=0.003; OR=3.19: 95% CI [1.43-7.12]). After binary logistic regression, cement dust was independently correlated with LC (p=0.042; OR=3.93; 95% CI [1.04-14.78]. The administration sector was associated with decreased risk (p=0.001; OR=0.07; 95% CI [0.03-0.15]) as well as the health sector (p=0.001; OR=0.098; 95% CI [0.02-0.43]). Conclusions: Our results supported the role of occupational factors in developing LC. Further studies enabling an in-depth analysis of occupational exposures are necessary to provide a clearer definition of the etiological associations between single agents and circumstances of exposure and the genesis of LC.


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References

1. Bouaouina N, Ouni S, Belajouza S, et al. Cancer du cavum d’emblée métastatique: étude clinique et pronostique (à propos de 51 cas). Pan Afr Med J. 2018;29:155.
2. Chu EA, Kim YJ. Laryngeal Cancer: Diagnosis and Preoperative Work-up. Otolaryngol Clin North Am. 2008; 41:673-695.
3. Price KA, Cohen E. Current treatment options for metastatic head and neck cancer. Curr Treat Options Oncol. 2012;13:35-46.
4. NIH. Surveillance, Epidemiology, and End Results (SEER) Stat Fact Sheets: Larynx Cancer. Available from: http://seer.cancer.gov/statfacts/html/larynx.html.
5. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Arsenic, metals, fibres, and dusts. IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt C):11-465
6. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Chemical agents and related occupations. IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt F):9-562.
7. Organisation international du Travail. Classification international du type de profession CITP
https://www.ilo.org/public/french/bureau/stat/isco/isco88/alpha.htm
8. Ashley P, Connell Ferster O, Schubart J, et al. Association Between Laryngeal Cancer and Asbestos Exposure A Systematic Review and meta-analysis. Jama Otolaryngol Head Neck Surg. 2016;143(4).
9. Paget-Bailly S, Cyr D, Luce D. Occupational exposures and cancer of the larynx: systematic review and meta-analysis. J Occup Environ Med. 2012;54:71-84.
10. Elci OC, Dosemeci M, Blair A. Occupation and the risk of laryngeal cancer in Turkey. Scand J Work Environ Health. 2001; 27(4):233-239.
11. Laakkonen A, Kauppinen T, Pukkala E. Cancer risk among Finnish food industry workers. Int J Cancer. 2006;118:2567-71.
12. Paget-Bailly S, Cyr D, Carton M, et al. Head and neck cancer and occupational exposure to asbestos, mineral wools and silica: results from the ICARE study. Occup Environ Med. 2014;71(1):A90-A90.
13. Ramroth H, AhrensW, Dietz A, Becher H. Occupational asbestos exposure as a risk factor for laryngeal carcinoma in a population-based case-control study from Germany. Am J Ind Med. 2011;54(7):510-514.
14. Grignoux J, Durand-Moreau Q, Vongmany N, Brunel S; Rnv3p members; Dewitte JD. Work-related laryngeal cancer: Trends in France from 2001 to 2016. Eur Ann Otorhinolaryngol Head Neck Dis. 2019;136(1):7-12. Doi: 10.1016/j.anorl.2018.10.006. Epub 2018 Oct 29. PMID: 30385255
15. Colin L S, Jhangry G J, Lakhani R, et al. Occupational exposure to sulfuric acid in southern Ontario, Canada, in association with laryngeal cancer. Scand J Work Environ Health. 1992;18:225-32.
16. Paget-Bailly S, Cyr D, Luce D. Occupational exposures to asbestos, polycyclic aromatic hydrocarbons and solvents, and cancers of the oral cavity and pharynx: a quantitative literature review. Int Arch Occup Environ Health. 2012;85(4):341-51.
17. International Agency for Research on Cancer. Wood dust and Formaldehyde. IARC Monographs on the evaluation of the carcinogenic risks to humans IARC.1995; 62.
18. Purdue MP, Järvholm B, Bergdahl IA, et al. Occupational exposures and head and neck cancers among Swedish construction workers. Scand J Work Environ Health. 2006; 32(4):270-5.
19. International Agency for Research on Cancer. Chromium, nickel and welding. Lyon (France): IARC; 1990. IARC monographs on the evaluation of carcinogenic risk to humans, vol 49.
20. Dietz A, Ramroth H, Urban T, Ahrens W, Becher H. Exposure to cement dust, related occupational groups and laryngeal cancer risk: results of a population based case-control study. Int J Cancer. 2004;108:907-11.
21. Paget-Bailly S, Guida F, Carton M, et al. Occupation and head and neck cancer risk in men: results from the ICARE study, a French population-based case–control study. J Occup Environ Med. 2013;55(9):1065-73.
22. Smailyte G. Cancer incidence among workers exposed to softwood dust in Lithuania. Occup Environ Med. 2012; 69:449-51.
23. Amizadeh M, Safari-Kamalabadi M, Askari-Saryazdi G, et al. Pesticide Exposure and Head and Neck Cancers: A Case-Control Study in an Agricultural Region. Iran J Otorhinolaryngol. 2017;92(5):Serial No.94, Sep.
24. IARC. Man-Made vitreous fibres. 2002;81:1-381.
25. Lipworth L, Bosetti C, Mc Laughlin JK. Occupational exposure to rock wool and glass wool and risk of cancers of the lung and the head and neck: a systematic review and meta-analysis. J Occup Environ Med. 2009; 51:1075-87.
26. Moulin JJ, Mur JM, Wild P, et al. Oral cavity and laryngeal cancers among man-made mineral fiber production workers. Scand J Work Environ Health. 1986;12:27-31.
27. Kogevinas M, Sala M, Boffetta P, et al. Cancer risk in the rubber industry: a review of the recent epidemiological evidence. Occup Environ Med. 1998; 55:1-12.
28. Boniol M, Koechlin A, Boyle P. Meta-analysis of occupational exposures in the rubber manufacturing industry and risk of cancer. Int J Epidemiol. 2017;46(6):1940-1947.
29. Chen M, Tse L. A. Laryngeal cancer and silica dust exposure: a systematic review and metaanalysis. Am J Ind Med. 2012;55(8):669-676.
30. Elci OC, Akpinar-Elci M, Blair A, Dosemeci M. Occupational dust exposure and the risk of laryngeal cancer in Turkey. Scand J Work Environ Health .2002;28:278-284.
31. Kyyronen P, Kauppinen T, Pukkala EI. Occupational exposure to eight organic dusts and respiratory cancer among Finns. Occup Environ Med. 2006;63:726-33.
32. Shangina O. Occupational Exposure and Laryngeal and Hypopharyngeal Cancer Risk in Central and Eastern Europe. Am J Epidemiol. 2006; 164:367-75.
33. Barul C, Fayossé A, Carton M, et al. Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France. Environ Health. (2017);16:77.
34. Guha N, Loomis D, Guyton KZ, et al. Carcinogenicity of welding, molybdenum trioxide, and indium tin oxide. Lancet Oncol. 2017;18(5):581-2.
35. Gustavsson P, Jakobsson R, Johansson H, et al. Occupational exposures and squamous cell carcinoma of the oral cavity, pharynx, larynx, and oesophagus: a case-control study in Sweden. Occup Environ Med. 1998;55(6):393-400.
36. Bayer O, Cámara R, Zeissig SR, et al. Occupation and cancer of the larynx: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2016;273(1):9-20.
37. Khlifi R, Olmedo P, Gil F, et al. A Risk of laryngeal and nasopharyngeal cancer associated with arsenic and cadmium in the Tunisian population. Environ Sci Pollut Res. 2014;21:2032-2042.
38. IARC Working Group. FORMALDEHYDE. 2012; Available from: https://www.ncbi.nlm.nih.gov/books/NBK304432/
39. Berrino F, Richiardi L, Boffetta P, et al. Occupation and larynx and hypopharynx cancer: a job-exposure matrix approach in an international case-control study in France, Italy, Spain and Switzerland. Cancer Causes Control 2003;14(3):213-23.

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Dec 7, 2023
DOI: https://doi.org/10.23749/mdl.v114i6.14588

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1.
Gaddour A, Brahem A, Mosbah H, Sridi C, Saidane M, Kacem I, et al. Occupational Risk Factors for Laryngeal Cancer in Tunisia: A Case Control Study: Occupational Risk facors For Laryngeal cancer. Med Lav [Internet]. 2023 Dec. 7 [cited 2024 Nov. 17];114(6):e2023047. Available from: https://mattioli1885journals.com/index.php/lamedicinadellavoro/article/view/14588
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Vol. 114 No. 6 (2023)
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1.
Gaddour A, Brahem A, Mosbah H, Sridi C, Saidane M, Kacem I, et al. Occupational Risk Factors for Laryngeal Cancer in Tunisia: A Case Control Study: Occupational Risk facors For Laryngeal cancer. Med Lav [Internet]. 2023 Dec. 7 [cited 2024 Nov. 17];114(6):e2023047. Available from: https://mattioli1885journals.com/index.php/lamedicinadellavoro/article/view/14588
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