Incidence of malignant mesothelioma and asbestos exposure in the Emilia-Romagna region, Italy
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Keywords
Mesothelioma, Incidence, Exposure, Asbestos, Sector of working
Abstract
Background: The aim of this study is to describe the incidence of malignant mesothelioma (MM) and asbestos exposure in an Italian region in the period 1996-June 2021. Methods: The study included cases with microscopic confirmation and those with instrumental confirmation. For each case, information on sex, age, tumour site, morphology and date of diagnosis was collected, along with details of exposure to asbestos. Results: 3,097 cases of MM (2,233 males and 864 females) were registered: 90.8% with microscopic confirmation. A total of 2,840 cases involved the pleura (92%), 230 cases the peritoneum (7%), and a small number of cases the pericardium and testis (9 and 18, respectively). Most cases (78.0%) occurred after 65 years of age, while only 1.5% concerned individuals with age < 45 years. The standardized incidence rate for the entire period (adjusted to the 2000 Italian standard population and calculated per 100,000 person-years) was equal to 3.9 in males and 1.4 in females, and the trend showed an increase with age in both sexes. Concerning asbestos exposure, 79.7% of cases were exposed (86.7% males and 60.1% females). In 70.3%, exposure was occupational (83.4% males and 33.2% females), while 20.7% of females and 0.8% of males had familial exposure. Building construction, rolling stock manufacture/repair and metalworking were the most prevalent economic activities associated with occupational exposure. Conclusions:This study offers an overview of MM in an Italian region characterized by high incidence and high exposure due to its particular production activities.
References
2. Ministero della Salute. Piano Nazionale Amianto: Linee di intervento per un’azione coordinata delle amministrazioni statali e territoriali; Roma, marzo 2013.
3. Hughes S. Relazione sulle minacce per la salute sul luogo di lavoro legate all’amianto e le prospettive di eliminazione di tutto l’amianto esistente; Parlamento Europeo, Doc di seduta A7- 0025/2013.
4. Marinaccio A, Binazzi A, Marzio DD, et al. ReNaM Working Group. Pleural malignant mesothelioma epi-demic: incidence, modalities of asbestos exposure and occupations involved from the Italian National Register. Int J Cancer. 2012 May 1;130(9):2146-54.
5. Alessi M, Amadori D, Amunni G, et al. Stato dell’arte e prospettive in materia di contrasto alle patologie asbesto-correlate; Quaderni del Ministero della Salute, n° 15, maggio-giugno 2012.
6. Delgermaa V, Takahashi K, Park EK, Vinh Le G, Hara T, Sorahan T. Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008. Bull World Health Organ 2011; 89:716-24.
7. Bertazzi PA. Descriptive epidemiology of malignant mesothelioma. Med Lav. 2005;7(4):287-303.
8. Marinaccio A, Binazzi A, Branchi C, et al. Sesto Rapporto - Il Registro Nazionale dei Mesoteliomi. INAIL, Milan 2018.
9. Magnani C, Bianchi C, Chellini E, et al. III Consensus Conference on Malignant Mesothelioma of the Pleu-ra. Epidemiology, Public Health and Occupational Medicine related issues. Med Lav. 2015;106(5):325-32.
10. Alpert N, van Gerwen M, Taioli E. Epidemiology of mesothelioma in the 21st century in Europe and the United States, 40 years after restricted/banned asbestos use. Transl Lung Cancer Res. 2020;9(Suppl 1): S28-S38.
11. Goldberg M, Imbernon E, Rolland P, et al. The French National Mesothelioma Surveillance Program. Occup Environ Med. 2006 Jun;63(6):390-5.
12. Neumann V, Günthe S, Mülle KM, Fischer M. Malignant mesothelioma - German mesothelioma register 1987-1999. Int Arch Occup Environ Health. 2001 Aug;74(6):383-95.
13. Yeung P, Rogers A, Johnson A. Distribution of mesothelioma cases in different occupational groups and industries in Australia, 1979–1995. Appl Occup Environ Hyg. 1999;14:759–67. Doi:10.1080/104732299302189.
14. Park EK, Takahashi K, Hoshuyama T, et al. Global magnitude of reported and unreported mesothelioma. Environ Health Perspect. 2011 Apr;119(4):514-8.
15. Il registro nazionale dei mesoteliomi, VII rapporto, 2021. Tipolitografia Inail - Milano, dicembre 2021. ISBN-978-88-7484-716-7.
16. ICD O third edition Fritz AG: International Classification of Diseases for Oncology: ICD-O (ed 3). Gene-va. Switzerland. World Health Organization. 2000).
17. Nesti M, Adamoli S, Ammirabile F, et al. Linee Guida per la rilevazione e la definizione dei casi di mesote-lioma maligno e la trasmissione delle informazioni all’ISPESL da parte dei Centri Operativi Regionali. II Edizione. Roma, maggio 2004.
18. Mangone L, Storchi C, Bisceglia I, Romanelli A. Malignant Mesothelioma in the Italian region Emi-lia-Romagna: incidence and asbestos exposure update to 2020, Annals of Research in Oncology, Vol. 1(3), 199-208, 2021.
19. Romanelli A, Marinaccio A, Mirabelli D, et al. Progetto di ricerca ISPESL B/45/DML/03, I mesoteliomi maligni a localizzazione extrapleurica, 2005.
20. Robinson BW, Musk AW, Lake RA. Malignant mesothelioma. Lancet. 2005;366:397-408.
21. Chiappino G, Mensi C, Riboldi L, Rivolta G. Il rischio amianto nel settore tessile: indicazioni dal Registro Mesoteliomi Lombardia e definitiva conferma. Med Lav. 2003;94(6):521-30.
22. Sugarbaker PH, Welch LS, Mohamed F, Glehen O. A review of peritoneal mesothelioma at the Washing-ton Cancer Institute. Surg Oncol Clin N Am. 2003;12(3):605-21.
23. Britton M. The epidemiology of mesothelioma. Semin Oncol. 2002;29(1):51-61.
24. Huncharek M. Non-asbestos related diffuse malignant mesothelioma. Tumori. 2002; 88:1-9.
25. Mangone L, Romanelli A, Campari C, Candela S. Il mesotelioma maligno in Emilia-Romagna: incidenza ed esposizione ad amianto. Epid Prev. 2002;26(3):124-9.
26. Peto J, Decarli A, La Vecchia C, Levi F, Negri E. The European mesothelioma epidemic. Br J Cancer. 1999;79(¾):666-72.
27. Boffetta P. Health effects of asbestos exposure in humans: a quantitative assessment. Med Lav. 1998;89(6):471-80.
28. Spirtas R, Heineman EF, Bernstein L, et al. Malignant mesothelioma: attributable risk of asbestos expo-sure. Occup Environ Med. 1994; 51:804-11.
29. Mangone L, Di Felice E, Storchi C, et al. The effects of improving the mesothelioma surveillance network on sensitivity, timeliness in reporting and asbestos exposure assessment. Med Lav. 2017 Oct 27;108(5):367-76.
30. Baumann F, Carbone M. Environmental risk of mesothelioma in the United States: An emerging con-cern-epidemiological issues. J Toxicol Environ Health B Crit Rev.2016;19(5-6):231-249.
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