L-cysteine and zinc-L-carnosine in the therapy of chronic atrophic gastritis: clinical efficacy and tolerability

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L-cysteine and zinc-L-carnosine in the therapy of chronic atrophic gastritis: clinical efficacy and tolerability

Authors

  • Maria Piera Panozzo Department of Laboratory Medicine ULSS7 Pedemontana, Hospital Alto Vicentino, Santorso (VI), Italy
  • Stefano Rossi Department of Pharmacology, University of Ferrara, Italy
  • Kryssia Isabel Rodriguez Castro Endoscopy Unit, Department of Medicine ULSS7 Pedemontana, Hospital Alto Vicentino, Santorso (VI), Italy
  • Marilisa Franceschi Endoscopy Unit, Department of Medicine ULSS7 Pedemontana, Hospital Alto Vicentino, Santorso (VI), Italy
  • Alessandra Violi Endoscopy Unit, Department of Medicine ULSS7 Pedemontana, Hospital Alto Vicentino, Santorso (VI), Italy
  • Antonio Ferronato Endoscopy Unit, Department of Medicine ULSS7 Pedemontana, Hospital Alto Vicentino, Santorso (VI), Italy
  • Lorenzo Brozzi Endoscopy Unit, Department of Medicine ULSS7 Pedemontana, Hospital Alto Vicentino, Santorso (VI), Italy
  • Lorella Franzoni Department of Medicine and Surgery, University of Parma, Italy
  • Francesco Di Mario Department of Medicine and Surgery, University of Parma, Italy
  • Pellegrino Crafa Department of Medicine and Surgery, University of Parma, Parma (Italy)

Keywords:

Chronic Atrophic Gastritis, , L-cysteine, zinc-L-carnosine, Pepsinogen I, Gastrin 17, OLGA

Abstract

Background and aim: Chronic atrophic gastritis is characterized by gastric atrophy due to loss of the mucosa cells. Clinical manifestations are represented by gastrointestinal symptoms and/or alterations due to macronutrient deficiency. There is no specific therapy for CAG, although some medical devices appear promising: L-cysteine reduces acetaldehyde levels in the stomach , zinc L-carnosine shows direct cytoprotective and anti-inflammatory action. We evaluated, in CAG patients, the therapeutic efficacy and tolerability of both devices on the improvement of gastric functional picture and symptoms as compared to a control group.

Methods: 200 CAG patients were recruited and divided into: Group 1: L-cysteine 300 mg/daily; Group 2: zinc L-carnosine 75 mg/daily; Group 3: control group without any therapy. Patients were followed up for three months to evaluate the efficacy of both molecules and the possible appearance of side effects and adverse events.

Results: Increased serum PGI l (efficacy rate 37.1% and 21.3%) and decreased G17 levels (efficacy rate 41.3% and 58.7%) were found for L-cysteine and zinc L-carnosine, respectively. An improvement or no appearance of new symptoms was detected (65.7% for L-cysteine and 77.3% for zinc L-carnosine). Both devices appeared well tolerated (compliance rate of 100% for L-cysteine and 93.7% for zinc L-carnosine) and side effects were limited to manifestations that resolved after stopping therapy.

Conclusions: Clinical efficacy of both molecules on CAG patients management represents a promising result; however, further randomized prospective studies performed on larger series for a prolonged time and on individual pathology groups are mandatory to confirm these data.

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Panozzo MP, Rossi S, Rodriguez Castro KI, Franceschi M, Violi A, Ferronato A, et al. L-cysteine and zinc-L-carnosine in the therapy of chronic atrophic gastritis: clinical efficacy and tolerability. Acta Biomed [Internet]. [cited 2024 Jul. 26];95(4):e2024078. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/15672

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How to Cite

1.
Panozzo MP, Rossi S, Rodriguez Castro KI, Franceschi M, Violi A, Ferronato A, et al. L-cysteine and zinc-L-carnosine in the therapy of chronic atrophic gastritis: clinical efficacy and tolerability. Acta Biomed [Internet]. [cited 2024 Jul. 26];95(4):e2024078. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/15672