Allergic rhinoconjunctivitis: pathophysiological mechanism and new therapeutic approach

Main Article Content

Giorgio Ciprandi
Salvatore Leonardi
Anna Maria Zicari
Maria Angela Tosca
Gianluigi Marseglia

Keywords

allergic rhinoconjunctivitis, inflammation, immune response, nutraceuticals

Abstract

Allergic rhinoconjunctivitis (AR) is the most common IgE-mediated disease. A type2 immune response is involved in AR pathogenesis. Allergic inflammation is characterized by eosinophilic infiltrate and mediators release. AR treatment is usually based on medication prescription, including antihistamines and intranasal corticosteroids. However, medications may be prescribed for long periods and sometimes may be scarcely effective, thus aggressive strategy should be used. Therefore, complementary medicine is becoming attractive for patients at present. Nutraceuticals represent interesting therapeutic options in clinical practice. In this regard, a new compound has been designed containing Vitamin D3, Perilla extract, and quercetin.

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