Herpes Simplex Virus 1 encephalitis with normal cerebrospinal fluid after brain radiotherapy in a patient with glioblastoma. A case report and review of literature

Carlotta Mutti; Erica Curti; Rosario Ciliento; Andrea Melpignano; Irene Florindo; Lucia Zinno; Enrico Sasso; Liborio Parrino; Giovanni Pavesi; Anna Elisabetta Vaudano

doi:10.23750/abm.v90i2.8218

Herpes Simplex Virus 1 encephalitis with normal cerebrospinal fluid after brain radiotherapy in a patient with glioblastoma. A case report and review of literature

Authors

Carlotta Mutti Neurology Department, Parma Hospital
Erica Curti U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma
Rosario Ciliento U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma
Andrea Melpignano U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma
Irene Florindo U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specia-listica, Azienda Ospedaliero-Universitaria di Parma;
Lucia Zinno U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specia-listica, Azienda Ospedaliero-Universitaria di Parma;
Enrico Sasso U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma; b U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specialistica, Azienda Ospedaliero-Universitaria di Parma;
Liborio Parrino U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma; b U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specialistica, Azienda Ospedaliero-Universitaria di Parma;
Giovanni Pavesi a U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma; b U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specia-listica, Azienda Ospedaliero-Universitaria di Parma;
Anna Elisabetta Vaudano Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia;

Keywords:

Herpes Simplex Virus 1 (HSV1), Encephalitis, Glioblastoma, Radiotherapy

Abstract

Herpes simplex virus encephalitis (HSE) is the most common cause of letal encephalitis and its prevalence appears higher among oncologic patients who undergo brain radiotherapy (RT). We describe a case of 76-year-old woman with glioblastoma multiforme (GBM) who developed HSE shortly after brain RT. Cerebrospinal fluid analysis (CSF) was normal and the diagnosis was driven by brain MRI and EEG. Prompt introduction of antiviral therapy improved the clinical picture. We highlight the importance of EEG and brain MRI for the diagnosis and suggest the possibility of antiviral profilaxys in oncologic patients who undergo brain RT.

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Published

23-05-2019

Issue

Vol. 90 No. 2 (2019)

Section

CASE REPORTS

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

Mutti C, Curti E, Ciliento R, et al. Herpes Simplex Virus 1 encephalitis with normal cerebrospinal fluid after brain radiotherapy in a patient with glioblastoma. A case report and review of literature. Acta Biomed. 2019;90(2):327-330. doi:10.23750/abm.v90i2.8218

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