A practical management of children with antibiotic allergy

A practical management of children with antibiotic allergy


  • Elisabetta Calamelli Pediatric and Neonatology Unit, Imola Hospital, Imola (BO), Italy
  • Carlo Caffarelli Clinica Pediatrica, Dipartimento di Medicina e Chirurgia, Azienda Ospedaliero-Universitaria, Università di Parma, Italy
  • Fabrizio Franceschini UOC Pediatria, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Ancona, Italy
  • Francesca Saretta Pediatric Department, AAS2 Bassa Friulana-Isontina, Palmanova-Latisana, Italy; Pediatric Allergy Unit, Department of Medicine, Udine, Italy
  • Fabio Cardinale UOC di Pediatria, Azienda Ospedaliera-Universitaria “Consorziale-Policlinico”, Ospedale Pediatrico Giovanni XXIII, Bari, Italy
  • Roberto Bernardini Pediatric Unit, “San Giuseppe” Hospital, Empoli, Italy
  • Lucia Liotti Department of Pediatrics, Senigallia Hospital, Senigallia, Italy
  • Francesca Mori Allergy Unit, Department of Pediatric Medicine, Anna Meyer Children’s University Hospital, Florence, Italy
  • Giuseppe Crisafulli UO Allergologia, Dipartimento di Pediatria, Università di Messina, Italy
  • Silvia Caimmi Pediatric Clinic, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
  • Paolo Bottau Pediatric and Neonatology Unit, Imola Hospital, Imola (BO), Italy


Antibiotic allergy, betalactam, drug adverse reaction, hypersensitivity reactions, children, skin test, specific IgE, drug provocation test, basophil activation test


About 10% of the parents reported that their children are allergic to one drug and the betalactam antibiotics are the most frequently suspected. Even if most of the adverse events following antibiotic prescriptions to children are considered allergic, after a full allergy work-up only a few of the suspected reactions are confirmed. For this reason, many children are incorrectly labelled as “allergic” and this represents an important challenge for the choice of the antibiotic therapy in these “labelled” children, who are frequently improperly deprived of narrow-spectrum antibiotics because considered as allergic. When an allergic reaction is suspected a precise diagnosis and a choice of a safe and effective alternative is essential for the future antibiotic option. In the light of this, the main aim of this paper is to try to provide a practical approach to managing the individuals who have reported adverse reactions to antibiotics.




How to Cite

A practical management of children with antibiotic allergy. Acta Biomed [Internet]. 2019 Jan. 28 [cited 2024 Jun. 15];90(3-S):11-9. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/8157

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