A practical management of children with antibiotic allergy

Elisabetta Calamelli; Carlo Caffarelli; Fabrizio Franceschini; Francesca Saretta; Fabio Cardinale; Roberto Bernardini; Lucia Liotti; Francesca Mori; Giuseppe Crisafulli; Silvia Caimmi; Paolo Bottau

doi:10.23750/abm.v90i3-S.8157

A practical management of children with antibiotic allergy

Authors

Elisabetta Calamelli Pediatric and Neonatology Unit, Imola Hospital, Imola (BO), Italy
Carlo Caffarelli Clinica Pediatrica, Dipartimento di Medicina e Chirurgia, Azienda Ospedaliero-Universitaria, Università di Parma, Italy
Fabrizio Franceschini UOC Pediatria, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Ancona, Italy
Francesca Saretta Pediatric Department, AAS2 Bassa Friulana-Isontina, Palmanova-Latisana, Italy; Pediatric Allergy Unit, Department of Medicine, Udine, Italy
Fabio Cardinale UOC di Pediatria, Azienda Ospedaliera-Universitaria “Consorziale-Policlinico”, Ospedale Pediatrico Giovanni XXIII, Bari, Italy
Roberto Bernardini Pediatric Unit, “San Giuseppe” Hospital, Empoli, Italy
Lucia Liotti Department of Pediatrics, Senigallia Hospital, Senigallia, Italy
Francesca Mori Allergy Unit, Department of Pediatric Medicine, Anna Meyer Children’s University Hospital, Florence, Italy
Giuseppe Crisafulli UO Allergologia, Dipartimento di Pediatria, Università di Messina, Italy
Silvia Caimmi Pediatric Clinic, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
Paolo Bottau Pediatric and Neonatology Unit, Imola Hospital, Imola (BO), Italy

DOI: https://doi.org/10.23750/abm.v90i3-S.8157

Keywords:

Antibiotic allergy, betalactam, drug adverse reaction, hypersensitivity reactions, children, skin test, specific IgE, drug provocation test, basophil activation test

Abstract

About 10% of the parents reported that their children are allergic to one drug and the betalactam antibiotics are the most frequently suspected. Even if most of the adverse events following antibiotic prescriptions to children are considered allergic, after a full allergy work-up only a few of the suspected reactions are confirmed. For this reason, many children are incorrectly labelled as “allergic” and this represents an important challenge for the choice of the antibiotic therapy in these “labelled” children, who are frequently improperly deprived of narrow-spectrum antibiotics because considered as allergic. When an allergic reaction is suspected a precise diagnosis and a choice of a safe and effective alternative is essential for the future antibiotic option. In the light of this, the main aim of this paper is to try to provide a practical approach to managing the individuals who have reported adverse reactions to antibiotics.

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Published

28-01-2019

Issue

Vol. 90 No. 3-S (2019): Advances in pediatric drug allergy - Guest Editor: Carlo Caffarelli

Section

REVIEWS

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

Calamelli E, Caffarelli C, Franceschini F, et al. A practical management of children with antibiotic allergy. Acta Biomed. 2019;90(3-S):11-19. doi:10.23750/abm.v90i3-S.8157

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