Physiological roles of parathyroid hormone-related protein

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Ngan Kam Lai
Dorothy Martinez

Keywords

hypercalcemia, hyperparathyroid homrone related protein

Abstract

PTHrP is widely expressed and plays a physiological role in a variety of normal fetal and adult tissues. The insights into these roles and the proposed mechanisms come from animal studies through overexpression, mutation, or deletion of PTHrP. The normal physiologic functions of PTHrP in each of these tissues will be reviewed in detail. Lastly, we will also discuss humoral hypercalcemia of malignancy, benign conditions with falsely elevated PTHrP, and the pharmacological role of PTHrP in osteoporosis treatment.

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