An uncommon case of chronic myeloid leukemia with variant cytogenetic

An uncommon case of chronic myeloid leukemia with variant cytogenetic

Authors

  • Mohamed A Abdullah Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar
  • Aliaa Amer Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar
  • Zafar Nawaz Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar
  • Ali S Abdullah Department of Medical Education, Internal Medicine Section, Hamad Medical Corporation, Doha, Qatar
  • Ahmad Al-Sabbagh Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar;
  • Samah Kohla Clinical Pathology Department, Faculty of Medicine, AlAzhar University, Cairo, Egypt
  • Abdulqadir J Nashwan Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar
  • Mohamed A Yassin Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar

Keywords:

CML, variant cytogenetic, accelerated phase

Abstract

Chronic Myeloid Leukemia (CML) is myeloproliferative neoplasm characterized by Philadelphia chromosome which is a balanced translocation between chromosome 9 and 22 in 90% of cases. However, variant cytogenetic still happens in 5-10 % of cases, the importance of which is controversial as well as its response to therapy, prognosis and progression to acute leukemias. Here we report a male patient with CML and variant cytogenetic who responded to low dose of Dasatinib (50 mg daily).

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Published

03-04-2018

Issue

Vol. 89 No. 3-S (2018): Haematological malignancies in Qatar: from childhood to adulthood

Section

CASE REPORTS

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Abdullah MA, Amer A, Nawaz Z, et al. An uncommon case of chronic myeloid leukemia with variant cytogenetic. Acta Biomed. 2018;89(3-S):28-32. doi:10.23750/abm.v89i3-S.7217
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